| RRC ID |
63470
|
| 著者 |
Wu Y, Funato Y, Meschi E, Jovanoski KD, Miki H, Waddell S.
|
| タイトル |
Magnesium efflux from Drosophila Kenyon cells is critical for normal and diet-enhanced long-term memory.
|
| ジャーナル |
Elife
|
| Abstract |
Dietary magnesium (Mg2+) supplementation can enhance memory in young and aged rats. Memory-enhancing capacity was largely ascribed to increases in hippocampal synaptic density and elevated expression of the NR2B subunit of the NMDA-type glutamate receptor. Here we show that Mg2+ feeding also enhances long-term memory in Drosophila. Normal and Mg2+-enhanced fly memory appears independent of NMDA receptors in the mushroom body and instead requires expression of a conserved CNNM-type Mg2+-efflux transporter encoded by the unextended (uex) gene. UEX contains a putative cyclic nucleotide-binding homology domain and its mutation separates a vital role for uex from a function in memory. Moreover, UEX localization in mushroom body Kenyon cells (KCs) is altered in memory-defective flies harboring mutations in cAMP-related genes. Functional imaging suggests that UEX-dependent efflux is required for slow rhythmic maintenance of KC Mg2+. We propose that regulated neuronal Mg2+ efflux is critical for normal and Mg2+-enhanced memory.
|
| 巻・号 |
9
|
| 公開日 |
2020-11-26
|
| DOI |
10.7554/eLife.61339
|
| PII |
61339
|
| PMID |
33242000
|
| PMC |
PMC7843133
|
| MeSH |
Animals
Drosophila Proteins / metabolism
Drosophila melanogaster / metabolism*
Hippocampus / physiology*
Magnesium / metabolism*
Memory / physiology*
Mushroom Bodies / physiology
Neurons / physiology
Signal Transduction / physiology
|
| IF |
7.08
|
| リソース情報 |
| ショウジョウバエ |
CAS0002 |
