論文 - 詳細
| RRC ID | 63470 |
|---|---|
| 著者 | Wu Y, Funato Y, Meschi E, Jovanoski KD, Miki H, Waddell S. |
| タイトル | Magnesium efflux from Drosophila Kenyon cells is critical for normal and diet-enhanced long-term memory. |
| ジャーナル | Elife |
| Abstract |
Dietary magnesium (Mg2+) supplementation can enhance memory in young and aged rats. Memory-enhancing capacity was largely ascribed to increases in hippocampal synaptic density and elevated expression of the NR2B subunit of the NMDA-type glutamate receptor. Here we show that Mg2+ feeding also enhances long-term memory in Drosophila. Normal and Mg2+-enhanced fly memory appears independent of NMDA receptors in the mushroom body and instead requires expression of a conserved CNNM-type Mg2+-efflux transporter encoded by the unextended (uex) gene. UEX contains a putative cyclic nucleotide-binding homology domain and its mutation separates a vital role for uex from a function in memory. Moreover, UEX localization in mushroom body Kenyon cells (KCs) is altered in memory-defective flies harboring mutations in cAMP-related genes. Functional imaging suggests that UEX-dependent efflux is required for slow rhythmic maintenance of KC Mg2+. We propose that regulated neuronal Mg2+ efflux is critical for normal and Mg2+-enhanced memory. |
| 巻・号 | 9 |
| 公開日 | 2020-11-26 |
| DOI | 10.7554/eLife.61339 |
| PII | 61339 |
| PMID | 33242000 |
| PMC | PMC7843133 |
| MeSH | Animals Drosophila Proteins / metabolism Drosophila melanogaster / metabolism* Hippocampus / physiology* Magnesium / metabolism* Memory / physiology* Mushroom Bodies / physiology Neurons / physiology Signal Transduction / physiology |
| IF | 7.08 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 21 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | CAS0002 |