論文 - 詳細
| RRC ID | 63494 |
|---|---|
| 著者 | Nagahara H, Yamamoto A, Seno T, Obayashi H, Kida T, Nakabayashi A, Kukida Y, Fujioka K, Fujii W, Murakami K, Kohno M, Kawahito Y. |
| タイトル | Allograft inflammatory factor-1 in the pathogenesis of bleomycin-induced acute lung injury. |
| ジャーナル | Biosci Trends |
| Abstract |
Allograft inflammatory factor-1 (AIF-1) is a protein expressed by macrophages infiltrating the area around the coronary arteries of rats with an ectopic cardiac allograft. Some studies have shown that expression of AIF-1 increased in a mouse model of trinitrobenzene sulfonic acid-induced acute colitis and in acute cellular rejection of human cardiac allografts. These results suggest that AIF-1 is related to acute inflammation. The current study used bleomycin-induced acute lung injury to analyze the expression of AIF-1 and to examine its function in acute lung injury. Results showed that AIF-1 was significantly expressed in lung macrophages and increased in bronchoalveolar lavage fluid from mice with bleomycin-induced acute lung injury in comparison to control mice. Recombinant AIF-1 increased the production of IL-6 and TNF-α from RAW264.7 (a mouse macrophage cell line) and primary lung fibroblasts, and it also increased the production of KC (CXCL1) from lung fibroblasts. These results suggest that AIF-1 plays an important role in the mechanism underlying acute lung injury. |
| 巻・号 | 10(1) |
| ページ | 47-53 |
| 公開日 | 2016-2-1 |
| DOI | 10.5582/bst.2016.01027 |
| PMID | 26911661 |
| MeSH | Acute Lung Injury / chemically induced* Acute Lung Injury / complications Acute Lung Injury / metabolism* Acute Lung Injury / pathology Animals Bleomycin Bronchoalveolar Lavage Fluid / cytology Calcium-Binding Proteins / metabolism* Chemokine CXCL1 / metabolism Fibroblasts / metabolism Fibroblasts / pathology Humans Inflammation / complications Inflammation / pathology Interleukin-6 / metabolism Lung / pathology Macrophages, Alveolar / metabolism Macrophages, Alveolar / pathology Mice Mice, Inbred C57BL Microfilament Proteins / metabolism* RAW 264.7 Cells Tumor Necrosis Factor-alpha / metabolism |
| IF | 1.553 |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) |