RRC ID 6360
Author Ghazi A, Henis-Korenblit S, Kenyon C.
Title A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans.
Journal PLoS Genet
Abstract In Caenorhabditis elegans and Drosophila melanogaster, the aging of the soma is influenced by the germline. When germline-stem cells are removed, aging slows and lifespan is increased. The mechanism by which somatic tissues respond to loss of the germline is not well-understood. Surprisingly, we have found that a predicted transcription elongation factor, TCER-1, plays a key role in this process. TCER-1 is required for loss of the germ cells to increase C. elegans' lifespan, and it acts as a regulatory switch in the pathway. When the germ cells are removed, the levels of TCER-1 rise in somatic tissues. This increase is sufficient to trigger key downstream events, as overexpression of tcer-1 extends the lifespan of normal animals that have an intact reproductive system. Our findings suggest that TCER-1 extends lifespan by promoting the expression of a set of genes regulated by the conserved, life-extending transcription factor DAF-16/FOXO. Interestingly, TCER-1 is not required for DAF-16/FOXO to extend lifespan in animals with reduced insulin/IGF-1 signaling. Thus, TCER-1 specifically links the activity of a broadly deployed transcription factor, DAF-16/FOXO, to longevity signals from reproductive tissues.
Volume 5(9)
Pages e1000639
Published 2009-9-1
DOI 10.1371/journal.pgen.1000639
PMID 19749979
PMC PMC2729384
MeSH Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / growth & development Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Female Gene Expression Regulation, Developmental Germ Cells / growth & development Germ Cells / metabolism Longevity Male Peptide Elongation Factors / genetics Peptide Elongation Factors / metabolism* Reproduction Signal Transduction* Transcription Factors / genetics Transcription Factors / metabolism*
IF 5.175
Times Cited 60
C.elegans tm1452