論文 - 詳細
| RRC ID | 6360 |
|---|---|
| 著者 | Ghazi A, Henis-Korenblit S, Kenyon C. |
| タイトル | A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans. |
| ジャーナル | PLoS Genet |
| Abstract |
In Caenorhabditis elegans and Drosophila melanogaster, the aging of the soma is influenced by the germline. When germline-stem cells are removed, aging slows and lifespan is increased. The mechanism by which somatic tissues respond to loss of the germline is not well-understood. Surprisingly, we have found that a predicted transcription elongation factor, TCER-1, plays a key role in this process. TCER-1 is required for loss of the germ cells to increase C. elegans' lifespan, and it acts as a regulatory switch in the pathway. When the germ cells are removed, the levels of TCER-1 rise in somatic tissues. This increase is sufficient to trigger key downstream events, as overexpression of tcer-1 extends the lifespan of normal animals that have an intact reproductive system. Our findings suggest that TCER-1 extends lifespan by promoting the expression of a set of genes regulated by the conserved, life-extending transcription factor DAF-16/FOXO. Interestingly, TCER-1 is not required for DAF-16/FOXO to extend lifespan in animals with reduced insulin/IGF-1 signaling. Thus, TCER-1 specifically links the activity of a broadly deployed transcription factor, DAF-16/FOXO, to longevity signals from reproductive tissues. |
| 巻・号 | 5(9) |
| ページ | e1000639 |
| 公開日 | 2009-9-1 |
| DOI | 10.1371/journal.pgen.1000639 |
| PMID | 19749979 |
| PMC | PMC2729384 |
| MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / growth & development Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Female Gene Expression Regulation, Developmental Germ Cells / growth & development Germ Cells / metabolism Longevity Male Peptide Elongation Factors / genetics Peptide Elongation Factors / metabolism* Reproduction Signal Transduction* Transcription Factors / genetics Transcription Factors / metabolism* |
| IF | 5.175 |
| 引用数 | 60 |
| WOS 分野 | GENETICS & HEREDITY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | F1000Research |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1452 |