Reference - Detail
| RRC ID | 63805 |
|---|---|
| Author | Nakai S, Oyabu M, Hatazawa Y, Akashi S, Kitamura T, Miura S, Kamei Y. |
| Title | FOXO1 suppresses PGC-1β gene expression in skeletal muscles. |
| Journal | FEBS Open Bio |
| Abstract |
Peroxisome proliferator-activated receptor-gamma coactivator-1β (PGC-1β) is a transcriptional regulator whose increased expression activates energy expenditure-related genes in skeletal muscles. However, how PGC-1β is regulated remains largely unclear. Here, we show that PGC-1β gene expression is negatively correlated with the expression of a transcription factor, forkhead box protein O1 (FOXO1), whose expression is increased during muscle atrophy. In the skeletal muscles of FOXO1-overexpressing transgenic mice, PGC-1β gene expression is decreased. Denervation or plaster cast-based unloading, as well as fasting, increases endogenous FOXO1 expression in skeletal muscles, with decreased PGC-1β expression. In the skeletal muscles of FOXO1-knockout mice, the decrease in PGC-1β expression caused by fasting was attenuated. Tamoxifen-inducible FOXO1 activation in C2C12 myoblasts causes a marked decrease of PGC-1β expression. These findings together reveal that FOXO1 activation suppresses PGC-1β expression. During atrophy with FOXO1 activation, decreased PGC-1β may decrease energy expenditure and avoid wasting energy. |
| Volume | 10(7) |
| Pages | 1373-1388 |
| Published | 2020-7-1 |
| DOI | 10.1002/2211-5463.12898 |
| PMID | 32433820 |
| PMC | PMC7327905 |
| MeSH | Animals Forkhead Box Protein O1 / deficiency Forkhead Box Protein O1 / genetics Forkhead Box Protein O1 / metabolism* Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Muscle, Skeletal / metabolism* Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / genetics* Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / metabolism |
| IF | 2.231 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 5 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | C2C12(RCB0987) |