論文 - 詳細
| RRC ID | 6388 |
|---|---|
| 著者 | Langenhan T, Prömel S, Mestek L, Esmaeili B, Waller-Evans H, Hennig C, Kohara Y, Avery L, Vakonakis I, Schnabel R, Russ AP. |
| タイトル | Latrophilin signaling links anterior-posterior tissue polarity and oriented cell divisions in the C. elegans embryo. |
| ジャーナル | Dev Cell |
| Abstract |
Understanding the mechanisms that coordinate the orientation of cell division planes during embryogenesis and morphogenesis is a fundamental problem in developmental biology. Here we show that the orphan receptor lat-1, a homolog of vertebrate latrophilins, plays an essential role in the establishment of tissue polarity in the C. elegans embryo. We provide evidence that lat-1 is required for the alignment of cell division planes to the anterior-posterior axis and acts in parallel to known polarity and morphogenesis signals. lat-1 is a member of the Adhesion-GPCR protein family and is structurally related to flamingo/CELSR, an essential component of the planar cell polarity pathway. We dissect the molecular requirements of lat-1 signaling and implicate lat-1 in an anterior-posterior tissue polarity pathway in the premorphogenesis stage of C. elegans development. |
| 巻・号 | 17(4) |
| ページ | 494-504 |
| 公開日 | 2009-10-1 |
| DOI | 10.1016/j.devcel.2009.08.008 |
| PII | S1534-5807(09)00345-1 |
| PMID | 19853563 |
| PMC | PMC2819344 |
| MeSH | Animals Animals, Genetically Modified Caenorhabditis elegans / embryology* Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins Cell Division Cell Polarity* Embryo, Nonmammalian / cytology Embryo, Nonmammalian / metabolism Embryonic Development Gene Expression Regulation, Developmental* Immunoenzyme Techniques In Situ Hybridization Oogenesis Organogenesis RNA, Small Interfering / pharmacology Receptors, Peptide / physiology* Signal Transduction* Spindle Apparatus / physiology* |
| IF | 10.092 |
| 引用数 | 80 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm463 tm306 |