論文 - 詳細
RRC ID | 63893 |
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著者 | Yahagi H, Yahagi T, Furukawa M, Matsuzaki K. |
タイトル | Antiproliferative and Antimigration Activities of Beauvericin Isolated from Isaria sp. on Pancreatic Cancer Cells. |
ジャーナル | Molecules |
Abstract |
This study describes the antiproliferative and antimigration effects of beauvericin from a culture broth of Isaria sp. in human pancreatic cancer cells (PANC-1). Activity-guided fractionation of the EtOAc extract of cultured broth of Isaria sp. RD055140 afforded beauvericin (1), a new isariotin derivative, 7-O-methylisariotin C (2), together with the known isariotin analogs, TK-57-164A (3) and B (4). As a result of the measurement of the cell viability, 1 inhibited cell growth (IC50 = 4.8 µM) of PANC-1 cells. Furthermore, 1 was found to inhibit the migration activity of PANC-1 cells by upregulating the expression of the E-cadherin gene and reducing N-cadherin and Snail genes in a dose-dependent manner (0.1-1 µM). These activities of 1 had lower concentrations than the cytotoxic activity. These findings suggest that 1 can be used as an anticancer agent against human pancreatic carcinoma. |
巻・号 | 25(19) |
公開日 | 2020-10-8 |
DOI | 10.3390/molecules25194586 |
PII | molecules25194586 |
PMID | 33050002 |
PMC | PMC7582479 |
MeSH | Antineoplastic Agents / pharmacology Cadherins / metabolism Cell Line, Tumor Cell Movement / drug effects* Cell Proliferation / drug effects* Cell Survival / drug effects Depsipeptides / pharmacology* Epoxy Compounds / pharmacology Heterocyclic Compounds, Bridged-Ring / pharmacology Humans Hypocreales / chemistry* Pancreas / drug effects Pancreas / metabolism Pancreatic Neoplasms / drug therapy* Pancreatic Neoplasms / metabolism Snail Family Transcription Factors / metabolism Up-Regulation / drug effects |
IF | 3.267 |
リソース情報 | |
ヒト・動物細胞 | PANC-1(RCB2095) |