| RRC ID |
63903
|
| Author |
Yamamoto M, Terada Y, Motoyama T, Shibata M, Saito T, Ito K.
|
| Title |
N-terminal [Glu]3 moiety of γ-glutamyl peptides contributes largely to the activation of human calcium-sensing receptor, a kokumi receptor.
|
| Journal |
Biosci Biotechnol Biochem
|
| Abstract |
γ-glutamyl peptides have been suggested to impart kokumi properties to foods by activating human calcium-sensing receptor (hCaSR). In this study, the relationship between γ-glutamyl peptide structure and hCaSR activity was systematically analyzed using γ-[Glu](n=0-4)-α-[Glu](n=0-3)-Tyr. Our results suggest that N-terminal [Glu]3 moiety is very important for hCaSR activities of γ-glutamyl peptides.
|
| Volume |
84(7)
|
| Pages |
1497-1500
|
| Published |
2020-7-1
|
| DOI |
10.1080/09168451.2020.1743169
|
| PMID |
32202205
|
| MeSH |
Calcium / analysis
Calcium / metabolism
Calcium Signaling / drug effects
Calcium Signaling / genetics*
Dipeptides / chemistry
Dipeptides / metabolism*
Glutathione / metabolism
HEK293 Cells
Humans
Naphthalenes / pharmacology
Oligopeptides / metabolism*
Receptors, Calcium-Sensing / antagonists & inhibitors
Receptors, Calcium-Sensing / genetics
Receptors, Calcium-Sensing / metabolism*
Taste / physiology
Transfection
|
| IF |
1.516
|
| Resource |
| Human and Animal Cells |
293T(RCB2202) |
