Reference - Detail
| RRC ID | 63918 |
|---|---|
| Author | Templeton GW, Johnson JJ, Sieben NA, Moorhead GB. |
| Title | GL2 EXPRESSION MODULATOR, a plant specific protein phosphatase one interactor that binds phosphoinositides. |
| Journal | Biochem Biophys Res Commun |
| Abstract |
Protein phosphatase one (PP1) is a major eukaryotic serine/threonine protein phosphatase whose activity is controlled by targeting or regulatory subunits. Currently, very few plant protein phosphatase one regulatory subunits are known. Here, Arabidopsis GL2 EXPRESSION MODULATOR (GEM) was identified and confirmed as a protein phosphatase one binding partner. GEM is a phosphoprotein, contains a highly conserved phosphoinositide binding GRAM domain and a classic protein phosphatase one binding RVXF motif. Lipid overlays show GEM has the ability to interact with phosphoinositides through its GRAM domain. GEM is the first plant specific protein phosphatase one interactor to be discovered. |
| Volume | 528(3) |
| Pages | 607-611 |
| Published | 2020-7-30 |
| DOI | 10.1016/j.bbrc.2020.05.137 |
| PII | S0006-291X(20)31065-2 |
| PMID | 32513542 |
| MeSH | Amino Acid Sequence Arabidopsis / genetics Arabidopsis / metabolism* Arabidopsis Proteins / chemistry Arabidopsis Proteins / genetics Arabidopsis Proteins / metabolism* Binding Sites / genetics Intracellular Signaling Peptides and Proteins / chemistry Intracellular Signaling Peptides and Proteins / genetics Intracellular Signaling Peptides and Proteins / metabolism* Phosphatidylinositols / metabolism* Protein Binding Protein Domains / genetics Protein Phosphatase 1 / metabolism |
| IF | 2.985 |
| Resource | |
| Arabidopsis / Cultured plant cells, genes | pda11581 |