RRC ID 6398
Author Reece-Hoyes JS, Deplancke B, Barrasa MI, Hatzold J, Smit RB, Arda HE, Pope PA, Gaudet J, Conradt B, Walhout AJ.
Title The C. elegans Snail homolog CES-1 can activate gene expression in vivo and share targets with bHLH transcription factors.
Journal Nucleic Acids Res
Abstract Snail-type transcription factors (TFs) are found in numerous metazoan organisms and function in a plethora of cellular and developmental processes including mesoderm and neuronal development, apoptosis and cancer. So far, Snail-type TFs are exclusively known as transcriptional repressors. They repress gene expression by recruiting transcriptional co-repressors and/or by preventing DNA binding of activators from the basic helix-loop-helix (bHLH) family of TFs to CAGGTG E-box sequences. Here we report that the Caenorhabditis elegans Snail-type TF CES-1 can activate transcription in vivo. Moreover, we provide results that suggest that CES-1 can share its binding site with bHLH TFs, in different tissues, rather than only occluding bHLH DNA binding. Together, our data indicate that there are at least two types of CES-1 target genes and, therefore, that the molecular function of Snail-type TFs is more plastic than previously appreciated.
Volume 37(11)
Pages 3689-98
Published 2009-6-1
DOI 10.1093/nar/gkp232
PII gkp232
PMID 19372275
PMC PMC2699517
MeSH Animals Basic Helix-Loop-Helix Transcription Factors / metabolism Binding Sites Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / metabolism* DNA-Binding Proteins / metabolism* Pharynx / metabolism Promoter Regions, Genetic Regulatory Elements, Transcriptional Transcription Factors / metabolism* Transcriptional Activation*
IF 11.502
Times Cited 23
C.elegans tm509 tm299