論文 - 詳細
| RRC ID | 6406 |
|---|---|
| 著者 | Menuz V, Howell KS, Gentina S, Epstein S, Riezman I, Fornallaz-Mulhauser M, Hengartner MO, Gomez M, Riezman H, Martinou JC. |
| タイトル | Protection of C. elegans from anoxia by HYL-2 ceramide synthase. |
| ジャーナル | Science |
| Abstract |
Oxygen deprivation is rapidly deleterious for most organisms. However, Caenorhabditis elegans has developed the ability to survive anoxia for at least 48 hours. Mutations in the DAF-2/DAF-16 insulin-like signaling pathway promote such survival. We describe a pathway involving the HYL-2 ceramide synthase that acts independently of DAF-2. Loss of the ceramide synthase gene hyl-2 results in increased sensitivity of C. elegans to anoxia. C. elegans has two ceramide synthases, hyl-1 and hyl-2, that participate in ceramide biogenesis and affect its ability to survive anoxic conditions. In contrast to hyl-2(lf) mutants, hyl-1(lf) mutants are more resistant to anoxia than normal animals. HYL-1 and HYL-2 have complementary specificities for fatty acyl chains. These data indicate that specific ceramides produced by HYL-2 confer resistance to anoxia. |
| 巻・号 | 324(5925) |
| ページ | 381-4 |
| 公開日 | 2009-4-17 |
| DOI | 10.1126/science.1168532 |
| PII | 324/5925/381 |
| PMID | 19372430 |
| MeSH | Animals Apoptosis Caenorhabditis elegans / cytology Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism* Cell Hypoxia* Ceramides / biosynthesis Ceramides / physiology* Gene Deletion Genes, Helminth Mutation Oxidoreductases / genetics* Oxidoreductases / metabolism* Oxygen / physiology* Receptor, Insulin / genetics Receptor, Insulin / metabolism Saccharomyces cerevisiae / genetics Saccharomyces cerevisiae / growth & development Saccharomyces cerevisiae / physiology Sphingomyelins / biosynthesis Sphingomyelins / physiology Substrate Specificity Transformation, Genetic Transgenes |
| IF | 41.846 |
| 引用数 | 104 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| リソース情報 | |
| 線虫 | tm2031 |