論文 - 詳細
| RRC ID | 64096 |
|---|---|
| 著者 | Arai MA, Ebihara I, Makita Y, Hara Y, Yaguchi T, Ishibashi M. |
| タイトル | Isolation of nocobactin NAs as Notch signal inhibitors from Nocardia farcinica, a possibility of invasive evolution. |
| ジャーナル | J Antibiot (Tokyo) |
| Abstract |
Notch signaling inhibitors with the potential of immune suppressor production by pathogenic bacteria for easy host infection were searched from extracts of Nocardia sp. Nocobactin NA-a (compound 1) and nocobactin NA-b (compound 2), which have been suggested as pathogenesis factors, were isolated from N. farcinica IFM 11523 isolated from the sputum of a Japanese patient with chronic bronchitis. Compounds 1 and 2 showed Notch inhibitory activities with IC50 values of 12.4 and 17.6 μM, respectively. Compound 1 and 2 decreased of Notch1 protein, Notch intracellular domain, and hairy and enhancer of split 1, which is a Notch signaling target protein. In addition, compounds 1 and 2 showed cytotoxicity against mouse macrophage-like cell line RAW264.7 with IC50 values of 18.9 and 21.1 μM, respectively. These results suggested that the Notch inhibitors production by pathogenic bacteria may increase pathogen infectivity. |
| 巻・号 | 74(4) |
| ページ | 255-259 |
| 公開日 | 2021-1-1 |
| DOI | 10.1038/s41429-020-00393-z |
| PII | 10.1038/s41429-020-00393-z |
| PMID | 33318622 |
| MeSH | Bronchitis, Chronic / microbiology Evolution, Molecular Host-Pathogen Interactions* Humans Hydroxamic Acids / isolation & purification Hydroxamic Acids / pharmacology Magnetic Resonance Spectroscopy Nocardia / growth & development Nocardia / isolation & purification Nocardia / metabolism Nocardia / pathogenicity* Nocardia Infections / microbiology* Oxazoles / isolation & purification Oxazoles / metabolism* Oxazoles / pharmacology Receptors, Notch / antagonists & inhibitors Receptors, Notch / metabolism* Signal Transduction Sputum / microbiology Virulence Factors / metabolism Virulence Factors / pharmacology |
| IF | 2.668 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 病原真核微生物 | Nocardia farcinica IFM 11523, IFM 645 |