論文 - 詳細
| RRC ID | 64114 |
|---|---|
| 著者 | Li GD, Kawashima H, Ogose A, Ariizumi T, Hotta T, Kuwano R, Urata Y, Fujiwara T, Endo N. |
| タイトル | Telomelysin shows potent antitumor activity through apoptotic and non-apoptotic cell death in soft tissue sarcoma cells. |
| ジャーナル | Cancer Sci |
| Abstract |
This study investigated the pathway underlying the antitumor activity of telomelysin, a telomerase-dependent, replication-selective oncolytic adenovirus, in soft tissue sarcoma cells. Treatment with telomelysin alone resulted in simultaneous induction of apoptosis and autophagy, whereas cotreatment with telomelysin and 3-methyladenine significantly reduced cell viability and increased apoptosis and the cellular ATP level compared to treatment with telomelysin alone, indicating that telomelysin-mediated autophagy is a death-protective but not death-promoting process. Cotreatment with Z-Val-Ala-Asp-CH2F significantly increased cellular ATP depletion compared to telomelysin-alone treatment while inhibiting telomelysin-induced apoptosis and having no significant effect on cell viability, indicating that it promotes transition from apoptotic to necrotic cell death. |
| 巻・号 | 104(9) |
| ページ | 1178-88 |
| 公開日 | 2013-9-1 |
| DOI | 10.1111/cas.12208 |
| PMID | 23718223 |
| PMC | PMC7656541 |
| MeSH | Adenine / analogs & derivatives Adenine / pharmacology Adenosine Triphosphate / metabolism Adenoviridae / metabolism* Adenoviridae Infections / metabolism Antineoplastic Agents / metabolism* Apoptosis / drug effects* Autophagy / drug effects Cell Death / drug effects* Cell Line, Tumor Cell Survival / drug effects HEK293 Cells HeLa Cells Humans Oncolytic Virotherapy / methods* Oncolytic Viruses / physiology* Sarcoma / drug therapy Sarcoma / metabolism Sarcoma / therapy* Sarcoma / virology* Telomerase / metabolism |
| IF | 4.966 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | HeLa |