RRC ID 64124
Author Yamashita J, Takeuchi A, Hosono K, Fleming T, Nagahama Y, Okubo K.
Title Male-predominant galanin mediates androgen-dependent aggressive chases in medaka.
Journal Elife
Abstract Recent studies in mice demonstrate that a subset of neurons in the medial preoptic area (MPOA) that express galanin play crucial roles in regulating parental behavior in both sexes. However, little information is available on the function of galanin in social behaviors in other species. Here, we report that, in medaka, a subset of MPOA galanin neurons occurred nearly exclusively in males, resulting from testicular androgen stimulation. Galanin-deficient medaka showed a greatly reduced incidence of male-male aggressive chases. Furthermore, while treatment of female medaka with androgen induced male-typical aggressive acts, galanin deficiency in these females attenuated the effect of androgen on chases. Given their male-biased and androgen-dependent nature, the subset of MPOA galanin neurons most likely mediate androgen-dependent male-male chases. Histological studies further suggested that variability in the projection targets of the MPOA galanin neurons may account for the species-dependent functional differences in these evolutionarily conserved neural substrates.
Volume 9
Published 2020-8-12
DOI 10.7554/eLife.59470
PII 59470
PMID 32783809
PMC PMC7423395
MeSH Androgens / metabolism* Animals Animals, Genetically Modified Cell Line Female Galanin / genetics Galanin / metabolism* Gene Expression HEK293 Cells Humans Male Neurons / metabolism Oryzias / metabolism* Preoptic Area / cytology Preoptic Area / metabolism Receptors, Galanin / metabolism Reproduction Sex Characteristics* Signal Transduction Steroids / metabolism
IF 7.08
Medaka BAC (ola1-108J05) d-rR/TOKYO (MT837)
Human and Animal Cells 293T(RCB2202)