RRC ID 64129
Author Ansai S, Mochida K, Fujimoto S, Mokodongan DF, Sumarto BKA, Masengi KWA, Hadiaty RK, Nagano AJ, Toyoda A, Naruse K, Yamahira K, Kitano J.
Title Genome editing reveals fitness effects of a gene for sexual dichromatism in Sulawesian fishes.
Journal Nat Commun
Abstract Sexual selection drives rapid phenotypic diversification of mating traits. However, we know little about the causative genes underlying divergence in sexually selected traits. Here, we investigate the genetic basis of male mating trait diversification in the medaka fishes (genus Oryzias) from Sulawesi, Indonesia. Using linkage mapping, transcriptome analysis, and genome editing, we identify csf1 as a causative gene for red pectoral fins that are unique to male Oryzias woworae. A cis-regulatory mutation enables androgen-induced expression of csf1 in male fins. csf1-knockout males have reduced red coloration and require longer for mating, suggesting that coloration can contribute to male reproductive success. Contrary to expectations, non-red males are more attractive to a predatory fish than are red males. Our results demonstrate that integrating genomics with genome editing enables us to identify causative genes underlying sexually selected traits and provides a new avenue for testing theories of sexual selection.
Volume 12(1)
Pages 1350
Published 2021-3-1
DOI 10.1038/s41467-021-21697-0
PII 10.1038/s41467-021-21697-0
PMID 33649298
PMC PMC7921647
MeSH Animal Fins / anatomy & histology Animals Female Gene Editing* Gene Expression Regulation Genetic Association Studies Genetic Fitness* Indonesia Macrophage Colony-Stimulating Factor / genetics Male Mutation / genetics Oryzias / genetics* Phylogeny Pigmentation / genetics Predatory Behavior Quantitative Trait Loci / genetics Sex Characteristics* Sexual Behavior, Animal
IF 12.121
Medaka O. celebensis (Ujung pandang) (RS278)