論文 - 詳細
| RRC ID | 64140 |
|---|---|
| 著者 | Arias Padilla LF, Castañeda-Cortés DC, Rosa IF, Moreno Acosta OD, Hattori RS, Nóbrega RH, Fernandino JI. |
| タイトル | Cystic proliferation of germline stem cells is necessary to reproductive success and normal mating behavior in medaka. |
| ジャーナル | Elife |
| Abstract |
The production of an adequate number of gametes is necessary for normal reproduction, for which the regulation of proliferation from early gonadal development to adulthood is key in both sexes. Cystic proliferation of germline stem cells is an especially important step prior to the beginning of meiosis; however, the molecular regulators of this proliferation remain elusive in vertebrates. Here, we report that ndrg1b is an important regulator of cystic proliferation in medaka. We generated mutants of ndrg1b that led to a disruption of cystic proliferation of germ cells. This loss of cystic proliferation was observed from embryogenic to adult stages, impacting the success of gamete production and reproductive parameters such as spawning and fertilization. Interestingly, the depletion of cystic proliferation also impacted male sexual behavior, with a decrease of mating vigor. These data illustrate why it is also necessary to consider gamete production capacity in order to analyze reproductive behavior. |
| 巻・号 | 10 |
| 公開日 | 2021-3-1 |
| DOI | 10.7554/eLife.62757 |
| PII | 62757 |
| PMID | 33646121 |
| PMC | PMC7946426 |
| MeSH | Animals Cell Cycle Proteins / genetics Cell Cycle Proteins / metabolism* Cell Proliferation* Female Germ Cells / cytology Germ Cells / growth & development* In Situ Hybridization Intracellular Signaling Peptides and Proteins / genetics Intracellular Signaling Peptides and Proteins / metabolism* Male Oryzias / genetics Oryzias / growth & development* Oryzias / physiology Sexual Behavior, Animal / physiology Transforming Growth Factor beta / antagonists & inhibitors |
| IF | 7.08 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 11 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| メダカ | hi-medaka (MT835) |