| RRC ID |
64152
|
| 著者 |
Koyama N, Nishida Y, Ishii T, Yoshida T, Furukawa Y, Narahara H.
|
| タイトル |
Telmisartan induces growth inhibition, DNA double-strand breaks and apoptosis in human endometrial cancer cells.
|
| ジャーナル |
PLoS One
|
| Abstract |
Telmisartan, an angiotensin II receptor type 1 blocker, is often used as an antihypertension drug, and it has also been characterized as a peroxisome proliferator-activated receptor-gamma (PPARγ) ligand. The purpose of this study was to elucidate the antitumor effects of telmisartan on endometrial cancer cells. We treated three endometrial cancer cell lines with various concentrations of telmisartan, and we investigated the effects of the telmisartan on the cell proliferation, apoptosis, and their related measurements in vitro. We also administered telmisartan to nude mice with experimental tumors to determine its in vivo effects and toxicity. All three endometrial cancer cell lines were sensitive to the growth-inhibitory effect of telmisartan. The induction of apoptosis was confirmed in concert with the altered expression of genes and proteins related to the apoptosis. We also observed that DNA double-strand breaks (DSBs) were induced in HHUA (human endometrial cancer) cells by telmisartan treatment. In addition, experiments in nude mice showed that telmisartan significantly inhibited human endometrial tumor growth, without toxic side effects. Our results suggest that telmisartan might be a new therapeutic option for the treatment of endometrial cancers.
|
| 巻・号 |
9(3)
|
| ページ |
e93050
|
| 公開日 |
2014-1-1
|
| DOI |
10.1371/journal.pone.0093050
|
| PII |
PONE-D-13-26968
|
| PMID |
24667764
|
| PMC |
PMC3965508
|
| MeSH |
Animals
Antineoplastic Agents / pharmacology*
Apoptosis / drug effects*
Benzimidazoles / pharmacology*
Benzoates / pharmacology*
Cell Proliferation / drug effects
Cell Survival / drug effects
DNA Breaks, Double-Stranded / drug effects*
Endometrial Neoplasms / genetics
Endometrial Neoplasms / pathology*
Female
Gene Expression Regulation, Neoplastic / drug effects
Humans
Membrane Potential, Mitochondrial / drug effects
Mice
Telmisartan
Xenograft Model Antitumor Assays
|
| IF |
2.74
|
| リソース情報 |
| ヒト・動物細胞 |
HHUA(RCB0658) |
