RRC ID 64153
著者 Takai N, Ueda T, Nasu K, Yamashita S, Toyofuku M, Narahara H.
タイトル Targeting calcium/calmodulin-dependence kinase I and II as a potential anti-proliferation remedy for endometrial carcinomas.
ジャーナル Cancer Lett
Abstract Calcium/calmodulin-dependent kinase (CaMK) I and II expression in endometrial cancer cells correlates with the malignant potential of this tumor, and CaMKI and II are potential therapeutic targets in endometrial cancer. CaMKI and II expression was significantly associated with PCNA-labeling index, clinical stage, histological grade, the presence of invasion to greater than one-half the myometrium, and clinical outcome. All endometrial cancer cell lines examined were sensitive to the growth-inhibitory effect of KN-93, a membrane-permeant CaMKs-selective inhibitor that is competitive with calmodulin. KN-93 induced the G0/G1 arrest and apoptosis, rising hopes that KN-93 may become a useful treatment for endometrial cancers.
巻・号 277(2)
ページ 235-43
公開日 2009-5-18
DOI 10.1016/j.canlet.2008.12.018
PII S0304-3835(08)00952-X
PMID 19168280
MeSH Antineoplastic Agents / pharmacology* Apoptosis / drug effects Benzylamines / pharmacology* Calcium-Calmodulin-Dependent Protein Kinase Type 1 / antagonists & inhibitors* Calcium-Calmodulin-Dependent Protein Kinase Type 1 / metabolism Calcium-Calmodulin-Dependent Protein Kinase Type 2 / antagonists & inhibitors* Calcium-Calmodulin-Dependent Protein Kinase Type 2 / metabolism Calmodulin / metabolism Cell Cycle / drug effects Cell Cycle / physiology Cell Line, Tumor Cell Proliferation / drug effects* Endometrial Neoplasms Female Humans Sulfonamides / pharmacology*
IF 7.36
リソース情報
ヒト・動物細胞 HHUA(RCB0658)