論文 - 詳細
| RRC ID | 64178 |
|---|---|
| 著者 | Sun S, Omar AM, Kim MJ, Phan ND, Chulikhit Y, Awale S. |
| タイトル | Chemical constituents of Thai Piper ribesoides and their antiausterity activities against the PANC-1 human pancreatic cancer cell line. |
| ジャーナル | Fitoterapia |
| Abstract |
A methanolic extract of Thai Piper ribesoides showed preferential cytotoxicity against PANC-1 human pancreatic cancer cells under a nutrient-deprived condition, with a PC50 value of 24 μg/mL. Phytochemical investigation of this bio-active extract led to the isolation of six compounds (1-6), including two new polyoxygenated cyclohexane derivatives, named ribesoidones A and B (1 and 2). The structural elucidation of the new compounds was achieved by a combination of HREIMS, NMR, and circular dichroism spectroscopic analyses. Isolated compounds were tested for their antiausterity activity against PANC-1 human pancreatic cancer cell line. Among these, compounds 1, 3, and 4 displayed potent preferential cytotoxic activity with PC50 values of 5.5-7.2 μM. Ribesoidone A (1) was also found to inhibit PANC-1 colony formation under normal nutrient-rich conditions. |
| 巻・号 | 151 |
| ページ | 104901 |
| 公開日 | 2021-6-1 |
| DOI | 10.1016/j.fitote.2021.104901 |
| PII | S0367-326X(21)00076-9 |
| PMID | 33794305 |
| MeSH | Antineoplastic Agents, Phytogenic / isolation & purification Antineoplastic Agents, Phytogenic / pharmacology* Cell Line, Tumor Drug Screening Assays, Antitumor Humans Molecular Structure Pancreatic Neoplasms / drug therapy Pancreatic Neoplasms / pathology* Phytochemicals / isolation & purification Phytochemicals / pharmacology Piper / chemistry* Plant Stems / chemistry Thailand |
| IF | 2.527 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | PANC-1(RCB2095) |