| RRC ID |
64179
|
| 著者 |
Fukuoka M, Fujita H, Numao K, Nakamura Y, Shimizu H, Sekiguchi M, Hohjoh H.
|
| タイトル |
MiR-199-3p enhances muscle regeneration and ameliorates aged muscle and muscular dystrophy.
|
| ジャーナル |
Commun Biol
|
| Abstract |
Parabiosis experiments suggest that molecular factors related to rejuvenation and aging circulate in the blood. Here, we show that miR-199-3p, which circulates in the blood as a cell-free miRNA, is significantly decreased in the blood of aged mice compared to young mice; and miR-199-3p has the ability to enhance myogenic differentiation and muscle regeneration. Administration of miR-199 mimics, which supply miR-199-3p, to aged mice resulted in muscle fiber hypertrophy and delayed loss of muscle strength. Systemic administration of miR-199 mimics to mdx mice, a well-known animal model of Duchenne muscular dystrophy (DMD), markedly improved the muscle strength of mice. Taken together, cell-free miR-199-3p in the blood may have an anti-aging effect such as a hypertrophic effect in aged muscle fibers and could have potential as a novel RNA therapeutic for DMD as well as age-related diseases. The findings provide us with new insights into blood-circulating miRNAs as age-related molecules.
|
| 巻・号 |
4(1)
|
| ページ |
427
|
| 公開日 |
2021-3-29
|
| DOI |
10.1038/s42003-021-01952-2
|
| PII |
10.1038/s42003-021-01952-2
|
| PMID |
33782502
|
| PMC |
PMC8007565
|
| MeSH |
Aging / physiology*
Animals
Disease Models, Animal
Male
Mice
Mice, Inbred C57BL
Mice, Inbred mdx
MicroRNAs / metabolism*
Muscle, Skeletal / physiopathology*
Muscular Dystrophy, Duchenne / genetics*
Muscular Dystrophy, Duchenne / physiopathology
Regeneration / genetics
Regeneration / physiology*
|
| IF |
4.165
|
| リソース情報 |
| ヒト・動物細胞 |
C2C12(RCB0987) |
