論文 - 詳細
| RRC ID | 64179 |
|---|---|
| 著者 | Fukuoka M, Fujita H, Numao K, Nakamura Y, Shimizu H, Sekiguchi M, Hohjoh H. |
| タイトル | MiR-199-3p enhances muscle regeneration and ameliorates aged muscle and muscular dystrophy. |
| ジャーナル | Commun Biol |
| Abstract |
Parabiosis experiments suggest that molecular factors related to rejuvenation and aging circulate in the blood. Here, we show that miR-199-3p, which circulates in the blood as a cell-free miRNA, is significantly decreased in the blood of aged mice compared to young mice; and miR-199-3p has the ability to enhance myogenic differentiation and muscle regeneration. Administration of miR-199 mimics, which supply miR-199-3p, to aged mice resulted in muscle fiber hypertrophy and delayed loss of muscle strength. Systemic administration of miR-199 mimics to mdx mice, a well-known animal model of Duchenne muscular dystrophy (DMD), markedly improved the muscle strength of mice. Taken together, cell-free miR-199-3p in the blood may have an anti-aging effect such as a hypertrophic effect in aged muscle fibers and could have potential as a novel RNA therapeutic for DMD as well as age-related diseases. The findings provide us with new insights into blood-circulating miRNAs as age-related molecules. |
| 巻・号 | 4(1) |
| ページ | 427 |
| 公開日 | 2021-3-29 |
| DOI | 10.1038/s42003-021-01952-2 |
| PII | 10.1038/s42003-021-01952-2 |
| PMID | 33782502 |
| PMC | PMC8007565 |
| MeSH | Aging / physiology* Animals Disease Models, Animal Male Mice Mice, Inbred C57BL Mice, Inbred mdx MicroRNAs / metabolism* Muscle, Skeletal / physiopathology* Muscular Dystrophy, Duchenne / genetics* Muscular Dystrophy, Duchenne / physiopathology Regeneration / genetics Regeneration / physiology* |
| IF | 4.165 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 26 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | C2C12(RCB0987) |