Reference - Detail
| RRC ID | 6424 |
|---|---|
| Author | Tong A, Lynn G, Ngo V, Wong D, Moseley SL, Ewbank JJ, Goncharov A, Wu YC, Pujol N, Chisholm AD. |
| Title | Negative regulation of Caenorhabditis elegans epidermal damage responses by death-associated protein kinase. |
| Journal | Proc Natl Acad Sci U S A |
| Abstract |
Wounding of epidermal layers triggers multiple coordinated responses to damage. We show here that the Caenorhabditis elegans ortholog of the tumor suppressor death-associated protein kinase, dapk-1, acts as a previously undescribed negative regulator of barrier repair and innate immune responses to wounding. Loss of DAPK-1 function results in constitutive formation of scar-like structures in the cuticle, and up-regulation of innate immune responses to damage. Overexpression of DAPK-1 represses innate immune responses to needle wounding. Up-regulation of innate immune responses in dapk-1 requires the TIR-1/p38 signal transduction pathway; loss of function in this pathway synergizes with dapk-1 to drastically reduce adult lifespan. Our results reveal a previously undescribed function for the DAPK tumor suppressor family in regulation of epithelial damage responses. |
| Volume | 106(5) |
| Pages | 1457-61 |
| Published | 2009-2-3 |
| DOI | 10.1073/pnas.0809339106 |
| PII | 0809339106 |
| PMID | 19164535 |
| PMC | PMC2629440 |
| MeSH | Animals Apoptosis Regulatory Proteins / genetics Apoptosis Regulatory Proteins / metabolism* Caenorhabditis elegans / immunology* Calcium-Calmodulin-Dependent Protein Kinases / genetics Calcium-Calmodulin-Dependent Protein Kinases / metabolism* Death-Associated Protein Kinases Immunity, Innate Microscopy, Electron Mutation Signal Transduction |
| IF | 9.412 |
| Times Cited | 50 |
| WOS Category | CELL BIOLOGY |
| Resource | |
| C.elegans | tm3036 |