論文 - 詳細
| RRC ID | 6425 |
|---|---|
| 著者 | Parry JM, Velarde NV, Lefkovith AJ, Zegarek MH, Hang JS, Ohm J, Klancer R, Maruyama R, Druzhinina MK, Grant BD, Piano F, Singson A. |
| タイトル | EGG-4 and EGG-5 Link Events of the Oocyte-to-Embryo Transition with Meiotic Progression in C. elegans. |
| ジャーナル | Curr Biol |
| Abstract |
The molecular underpinnings of the oocyte-to-embryo transition are poorly understood. Here we show that two protein tyrosine phosphatase-like (PTPL) family proteins, EGG-4 and EGG-5, are required for key events of the oocyte-to-embryo transition in Caenorhabditis elegans. The predicted EGG-4 and EGG-5 amino acid sequences are 99% identical and their functions are redundant. In embryos lacking EGG-4 and EGG-5, we observe defects in meiosis, polar body formation, the block to polyspermy, F-actin dynamics, and eggshell deposition. During oogenesis, EGG-4 and EGG-5 assemble at the oocyte cortex with the previously identified regulators or effectors of the oocyte-to-embryo transition EGG-3, CHS-1, and MBK-2 [1, 2]. All of these molecules share a complex interdependence with regards to their dynamics and subcellular localization. Shortly after fertilization, EGG-4 and EGG-5 are required to properly coordinate a redistribution of CHS-1 and EGG-3 away from the cortex during meiotic anaphase I. Therefore, EGG-4 and EGG-5 are not only required for critical events of the oocyte-to-embryo transition but also link the dynamics of the regulatory machinery with the advancing cell cycle. |
| 巻・号 | 19(20) |
| ページ | 1752-7 |
| 公開日 | 2009-11-3 |
| DOI | 10.1016/j.cub.2009.09.015 |
| PII | S0960-9822(09)01692-3 |
| PMID | 19879147 |
| PMC | PMC2783797 |
| MeSH | Amino Acid Sequence Animals Caenorhabditis elegans / embryology* Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / analysis Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / physiology* Chitin Synthase / analysis Chitin Synthase / genetics Chitin Synthase / physiology Cytoplasm / metabolism Embryonic Development / genetics* Meiosis / physiology* Molecular Sequence Data Oocytes / cytology Oocytes / growth & development Oocytes / metabolism Protein Transport Protein-Tyrosine Kinases / analysis Protein-Tyrosine Kinases / genetics Protein-Tyrosine Kinases / physiology Sequence Alignment |
| IF | 9.601 |
| 引用数 | 50 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1508 |