論文 - 詳細
| RRC ID | 64307 |
|---|---|
| 著者 | Ackerman SD, Perez-Catalan NA, Freeman MR, Doe CQ. |
| タイトル | Astrocytes close a motor circuit critical period. |
| ジャーナル | Nature |
| Abstract |
Critical periods-brief intervals during which neural circuits can be modified by activity-are necessary for proper neural circuit assembly. Extended critical periods are associated with neurodevelopmental disorders; however, the mechanisms that ensure timely critical period closure remain poorly understood1,2. Here we define a critical period in a developing Drosophila motor circuit and identify astrocytes as essential for proper critical period termination. During the critical period, changes in activity regulate dendrite length, complexity and connectivity of motor neurons. Astrocytes invaded the neuropil just before critical period closure3, and astrocyte ablation prolonged the critical period. Finally, we used a genetic screen to identify astrocyte-motor neuron signalling pathways that close the critical period, including Neuroligin-Neurexin signalling. Reduced signalling destabilized dendritic microtubules, increased dendrite dynamicity and impaired locomotor behaviour, underscoring the importance of critical period closure. Previous work defined astroglia as regulators of plasticity at individual synapses4; we show here that astrocytes also regulate motor circuit critical period closure to ensure proper locomotor behaviour. |
| 巻・号 | 592(7854) |
| ページ | 414-420 |
| 公開日 | 2021-4-1 |
| DOI | 10.1038/s41586-021-03441-2 |
| PII | 10.1038/s41586-021-03441-2 |
| PMID | 33828296 |
| MeSH | Animals Astrocytes / physiology* Cell Adhesion Molecules, Neuronal / metabolism Critical Period, Psychological* Dendrites / physiology Drosophila melanogaster / cytology* Drosophila melanogaster / physiology* Efferent Pathways / physiology* Female Locomotion / physiology Male Microtubules / metabolism Motor Neurons / physiology* Neuronal Plasticity / physiology* Neuropil / physiology Receptors, Cell Surface / metabolism Signal Transduction Synapses / physiology Time Factors |
| IF | 42.779 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 192 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | HMJ22218 HMJ22056 HMJ21692 |