RRC ID |
64355
|
著者 |
Ojiro I, Nishio H, Yamazaki-Ito T, Nakano S, Ito S, Toyohara Y, Hiramoto T, Terada Y, Ito K.
|
タイトル |
Trp-Trp acts as a multifunctional blocker for human bitter taste receptors, hTAS2R14, hTAS2R16, hTAS2R43, and hTAS2R46.
|
ジャーナル |
Biosci Biotechnol Biochem
|
Abstract |
Many functional food ingredients activate human bitter taste receptors (hTAS2Rs). In this study, A novel inhibitor, Trp-Trp, for hTAS2R14 was identified by searching for the agonist peptide's analogs. Trp-Trp also inhibited hTAS2R16, hTAS2R43, and hTAS2R46, which share the same agonists with hTAS2R14. The multi-functional characteristic of Trp-Trp is advantageous for use as bitterness-masking agents in functional foods.
|
巻・号 |
85(6)
|
ページ |
1526-1529
|
公開日 |
2021-5-25
|
DOI |
10.1093/bbb/zbab061
|
PII |
6223520
|
PMID |
33844825
|
MeSH |
Dipeptides / pharmacology*
Functional Food / analysis
Humans
Receptors, G-Protein-Coupled / antagonists & inhibitors*
Taste / drug effects
|
IF |
1.516
|
リソース情報 |
ヒト・動物細胞 |
293T(RCB2202) |