論文 - 詳細
| RRC ID | 6442 |
|---|---|
| 著者 | Zhang Y, Yan L, Zhou Z, Yang P, Tian E, Zhang K, Zhao Y, Li Z, Song B, Han J, Miao L, Zhang H. |
| タイトル | SEPA-1 mediates the specific recognition and degradation of P granule components by autophagy in C. elegans. |
| ジャーナル | Cell |
| Abstract |
How autophagy, an evolutionarily conserved intracellular catabolic system for bulk degradation, selectively degrades protein aggregates is poorly understood. Here, we show that several maternally derived germ P granule components are selectively eliminated by autophagy in somatic cells during C. elegans embryogenesis. The activity of sepa-1 is required for the degradation of these P granule components and for their accumulation into aggregates, termed PGL granules, in autophagy mutants. SEPA-1 forms protein aggregates and is also a preferential target of autophagy. SEPA-1 directly binds to the P granule component PGL-3 and also to the autophagy protein LGG-1/Atg8. SEPA-1 aggregates consistently colocalize with PGL granules and with LGG-1 puncta. Thus, SEPA-1 functions as a bridging molecule in mediating the specific recognition and degradation of P granule components by autophagy. Our study reveals a mechanism for preferential degradation of protein aggregates by autophagy and emphasizes the physiological significance of selective autophagy during animal development. |
| 巻・号 | 136(2) |
| ページ | 308-21 |
| 公開日 | 2009-1-23 |
| DOI | 10.1016/j.cell.2008.12.022 |
| PII | S0092-8674(08)01614-0 |
| PMID | 19167332 |
| MeSH | Amino Acid Sequence Animals Autophagy* Caenorhabditis elegans / cytology* Caenorhabditis elegans / embryology* Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / chemistry Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Carrier Proteins / chemistry Carrier Proteins / genetics Carrier Proteins / metabolism* Cytoplasmic Granules / metabolism* Disorders of Sex Development Extrachromosomal Inheritance Male Molecular Sequence Data RNA-Binding Proteins / genetics RNA-Binding Proteins / metabolism |
| IF | 38.637 |
| 引用数 | 143 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | F1000Research |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1642 tm2976 |