論文 - 詳細
| RRC ID | 64461 |
|---|---|
| 著者 | Rust K, Byrnes LE, Yu KS, Park JS, Sneddon JB, Tward AD, Nystul TG. |
| タイトル | A single-cell atlas and lineage analysis of the adult Drosophila ovary. |
| ジャーナル | Nat Commun |
| Abstract |
The Drosophila ovary is a widely used model for germ cell and somatic tissue biology. Here we use single-cell RNA-sequencing (scRNA-seq) to build a comprehensive cell atlas of the adult Drosophila ovary that contains transcriptional profiles for every major cell type in the ovary, including the germline stem cells and their niche cells, follicle stem cells, and previously undescribed subpopulations of escort cells. In addition, we identify Gal4 lines with specific expression patterns and perform lineage tracing of subpopulations of escort cells and follicle cells. We discover that a distinct subpopulation of escort cells is able to convert to follicle stem cells in response to starvation or upon genetic manipulation, including knockdown of escargot, or overactivation of mTor or Toll signalling. |
| 巻・号 | 11(1) |
| ページ | 5628 |
| 公開日 | 2020-11-6 |
| DOI | 10.1038/s41467-020-19361-0 |
| PII | 10.1038/s41467-020-19361-0 |
| PMID | 33159074 |
| PMC | PMC7648648 |
| MeSH | Animals Cell Lineage Drosophila / cytology* Drosophila / genetics Drosophila / metabolism Drosophila Proteins / genetics Drosophila Proteins / metabolism Female Ovarian Follicle / cytology Ovarian Follicle / metabolism Ovary / cytology* Ovary / metabolism Single-Cell Analysis |
| IF | 12.121 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 10 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#112322 |