論文 - 詳細
| RRC ID | 64477 |
|---|---|
| 著者 | Shrestha B, Lee Y. |
| タイトル | Mechanisms of DEET gustation in Drosophila. |
| ジャーナル | Insect Biochem Mol Biol |
| Abstract |
DEET is the most widely used active ingredient in insect repellents and offers protection against insect bites. We previously reported that DEET suppresses the feeding behavior of Drosophila, which is guided by gustatory receptors (GRs) in bitter-sensing gustatory receptor neurons. Here, we sought to identify new candidates using egg-laying assays. Upon screening all GR mutants, GR89a was identified as a potential DEET receptor. Gr89a mutants exhibited reduced oviposition avoidance, feeding avoidance, and electrophysiological responses compared to Gr32a, Gr33a, and Gr66a mutants. However, GR89a was found to modulate DEET avoidance, as demonstrated by genetic and RNA interference assays. Furthermore, we found that DEET ingestion severely affected larval and pupal development and survival, and therefore may act as an effective larvicide. |
| 巻・号 | 131 |
| ページ | 103550 |
| 公開日 | 2021-4-1 |
| DOI | 10.1016/j.ibmb.2021.103550 |
| PII | S0965-1748(21)00033-3 |
| PMID | 33549816 |
| MeSH | Animals DEET / pharmacology* Drosophila Proteins / genetics Drosophila melanogaster / drug effects Drosophila melanogaster / physiology Feeding Behavior / drug effects Feeding Behavior / physiology Insect Repellents / pharmacology Larva / drug effects Mutation Oviposition / drug effects* Receptors, Cell Surface / genetics Taste / drug effects* |
| IF | 3.827 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 18531R-2 HMJ30111 HMJ30319 HMJ21905 HMJ23092 HMS01680 HMJ22854 HMJ22987 HMJ23292 HMJ23106 |