RRC ID 64484
著者 Park JS, Kim YJ.
タイトル Anti-Aging Effect of the Ketone Metabolite β-Hydroxybutyrate in Drosophila Intestinal Stem Cells.
ジャーナル Int J Mol Sci
Abstract Age-related changes in tissue-resident adult stem cells may be closely linked to tissue aging and age-related diseases, such as cancer. β-Hydroxybutyrate is emerging as an important molecule for exhibiting the anti-aging effects of caloric restriction and fasting, which are generally considered to be beneficial for stem cell maintenance and tissue regeneration. The effects of β-hydroxybutyrate on adult stem cells remain largely unknown. Therefore, this study was undertaken to investigate whether β-hydroxybutyrate supplementation exerts beneficial effects on age-related changes in intestinal stem cells that were derived from the Drosophila midgut. Our results indicate that β-hydroxybutyrate inhibits age- and oxidative stress-induced changes in midgut intestinal stem cells, including centrosome amplification (a hallmark of cancers), hyperproliferation, and DNA damage accumulation. Additionally, β-hydroxybutyrate inhibits age- and oxidative stress-induced heterochromatin instability in enterocytes, an intestinal stem cells niche cells. Our results suggest that β-hydroxybutyrate exerts both intrinsic as well as extrinsic influence in order to maintain stem cell homeostasis.
巻・号 21(10)
公開日 2020-5-15
DOI 10.3390/ijms21103497
PII ijms21103497
PMID 32429095
PMC PMC7278929
MeSH 3-Hydroxybutyric Acid / pharmacology* Aging / drug effects* Animals Centrosome / metabolism DNA Damage Drosophila melanogaster / cytology* Drosophila melanogaster / physiology* Heterochromatin / metabolism Intestines / cytology* Ketones / metabolism* Metabolome* / drug effects Oxidative Stress / drug effects Stem Cell Niche / drug effects Stem Cells / cytology* Stem Cells / drug effects
IF 4.556
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