論文 - 詳細
| RRC ID | 64484 |
|---|---|
| 著者 | Park JS, Kim YJ. |
| タイトル | Anti-Aging Effect of the Ketone Metabolite β-Hydroxybutyrate in Drosophila Intestinal Stem Cells. |
| ジャーナル | Int J Mol Sci |
| Abstract |
Age-related changes in tissue-resident adult stem cells may be closely linked to tissue aging and age-related diseases, such as cancer. β-Hydroxybutyrate is emerging as an important molecule for exhibiting the anti-aging effects of caloric restriction and fasting, which are generally considered to be beneficial for stem cell maintenance and tissue regeneration. The effects of β-hydroxybutyrate on adult stem cells remain largely unknown. Therefore, this study was undertaken to investigate whether β-hydroxybutyrate supplementation exerts beneficial effects on age-related changes in intestinal stem cells that were derived from the Drosophila midgut. Our results indicate that β-hydroxybutyrate inhibits age- and oxidative stress-induced changes in midgut intestinal stem cells, including centrosome amplification (a hallmark of cancers), hyperproliferation, and DNA damage accumulation. Additionally, β-hydroxybutyrate inhibits age- and oxidative stress-induced heterochromatin instability in enterocytes, an intestinal stem cells niche cells. Our results suggest that β-hydroxybutyrate exerts both intrinsic as well as extrinsic influence in order to maintain stem cell homeostasis. |
| 巻・号 | 21(10) |
| 公開日 | 2020-5-15 |
| DOI | 10.3390/ijms21103497 |
| PII | ijms21103497 |
| PMID | 32429095 |
| PMC | PMC7278929 |
| MeSH | 3-Hydroxybutyric Acid / pharmacology* Aging / drug effects* Animals Centrosome / metabolism DNA Damage Drosophila melanogaster / cytology* Drosophila melanogaster / physiology* Heterochromatin / metabolism Intestines / cytology* Ketones / metabolism* Metabolome* / drug effects Oxidative Stress / drug effects Stem Cell Niche / drug effects Stem Cells / cytology* Stem Cells / drug effects |
| IF | 4.556 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 10 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#105669 DGRC#109126 |