論文 - 詳細
| RRC ID | 64541 |
|---|---|
| 著者 | Mori T, Murasawa Y, Ikai R, Hayakawa T, Nakamura H, Ogiso N, Niida S, Watanabe K. |
| タイトル | Generation of a transgenic mouse line for conditional expression of human IL-6. |
| ジャーナル | Exp Anim |
| Abstract |
IL-6 is a cytokine that is involved in various physiological and pathological conditions, and approaches using gain-of-function transgenic animals have contributed in elucidating IL-6 function. However, studies of the multiple functions of IL-6 in vivo are very time consuming because they require the generation of transgenic mice that harbor the gene encoding IL-6 under the control of specific promoters to mimic different pathologies. Here, we report the establishment of a conditional human IL-6 transgenic mouse, LGL-IL6, which conditionally expresses human IL-6 by taking advantage of the well-characterized Cre recombinase drivers. |
| 巻・号 | 65(4) |
| ページ | 455-463 |
| 公開日 | 2016-11-1 |
| DOI | 10.1538/expanim.16-0043 |
| PMID | 27349442 |
| PMC | PMC5111849 |
| MeSH | Animals Gene Expression* Humans Interleukin-6 / genetics* Interleukin-6 / metabolism Mice, Transgenic / genetics* Mice, Transgenic / metabolism |
| IF | 1.574 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 4.0 |
| リソース情報 | |
| ヒト・動物細胞 | 7-TD-1(RCB1190) |