RRC ID 64541
Author Mori T, Murasawa Y, Ikai R, Hayakawa T, Nakamura H, Ogiso N, Niida S, Watanabe K.
Title Generation of a transgenic mouse line for conditional expression of human IL-6.
Journal Exp Anim
Abstract IL-6 is a cytokine that is involved in various physiological and pathological conditions, and approaches using gain-of-function transgenic animals have contributed in elucidating IL-6 function. However, studies of the multiple functions of IL-6 in vivo are very time consuming because they require the generation of transgenic mice that harbor the gene encoding IL-6 under the control of specific promoters to mimic different pathologies. Here, we report the establishment of a conditional human IL-6 transgenic mouse, LGL-IL6, which conditionally expresses human IL-6 by taking advantage of the well-characterized Cre recombinase drivers.
Volume 65(4)
Pages 455-463
Published 2016-11-1
DOI 10.1538/expanim.16-0043
PMID 27349442
PMC PMC5111849
MeSH Animals Gene Expression* Humans Interleukin-6 / genetics* Interleukin-6 / metabolism Mice, Transgenic / genetics* Mice, Transgenic / metabolism
Resource
Human and Animal Cells 7-TD-1(RCB1190)