| RRC ID |
64663
|
| 著者 |
Sanchez-Aguilera A, Wheeler DW, Jurado-Parras T, Valero M, Nokia MS, Cid E, Fernandez-Lamo I, Sutton N, García-Rincón D, de la Prida LM, Ascoli GA.
|
| タイトル |
An update to Hippocampome.org by integrating single-cell phenotypes with circuit function in vivo.
|
| ジャーナル |
PLoS Biol
|
| Abstract |
Understanding brain operation demands linking basic behavioral traits to cell-type specific dynamics of different brain-wide subcircuits. This requires a system to classify the basic operational modes of neurons and circuits. Single-cell phenotyping of firing behavior during ongoing oscillations in vivo has provided a large body of evidence on entorhinal-hippocampal function, but data are dispersed and diverse. Here, we mined literature to search for information regarding the phase-timing dynamics of over 100 hippocampal/entorhinal neuron types defined in Hippocampome.org. We identified missing and unresolved pieces of knowledge (e.g., the preferred theta phase for a specific neuron type) and complemented the dataset with our own new data. By confronting the effect of brain state and recording methods, we highlight the equivalences and differences across conditions and offer a number of novel observations. We show how a heuristic approach based on oscillatory features of morphologically identified neurons can aid in classifying extracellular recordings of single cells and discuss future opportunities and challenges towards integrating single-cell phenotypes with circuit function.
|
| 巻・号 |
19(5)
|
| ページ |
e3001213
|
| 公開日 |
2021-5-1
|
| DOI |
10.1371/journal.pbio.3001213
|
| PII |
PBIOLOGY-D-20-03400
|
| PMID |
33956790
|
| PMC |
PMC8130934
|
| MeSH |
Action Potentials / physiology
Animals
Entorhinal Cortex / physiology
Hippocampus / anatomy & histology*
Hippocampus / metabolism*
Hippocampus / physiology*
Mice
Neurons / physiology
Phenotype
Rats
|
| IF |
7.076
|
| リソース情報 |
| ラット |
W-Tg(Slc32a1-YFP*)1Yyan (StrainID=905) |
