論文 - 詳細
| RRC ID | 64679 |
|---|---|
| 著者 | Haque M, Xiong X, Lei F, Das JK, Song J. |
| タイトル | An optimized protocol for the generation of HBV viral antigen-specific T lymphocytes from pluripotent stem cells. |
| ジャーナル | STAR Protoc |
| Abstract |
In T cell-based cancer immunotherapy, tumor antigen (Ag)-specific CD8+ cytotoxic T lymphocytes (CTLs) can specifically target tumor Ags on malignant cells. This promising approach drove us to adopt this strategy of T cell transfer (ACT)-based immunotherapy for chronic viral infections. Here, we describe the generation of hepatitis B virus (HBV) Ag-specific CTLs from induced pluripotent stem cells (iPSCs), i.e., iPSC-CTLs. Ag-specific iPSC-CTLs can target HBV Ag+ cells and infiltrate into the liver to suppress HBV replication in a murine model. For complete details on the use and execution of this protocol, please refer to Haque et al. (2020). |
| 巻・号 | 2(1) |
| ページ | 100264 |
| 公開日 | 2021-3-19 |
| DOI | 10.1016/j.xpro.2020.100264 |
| PII | S2666-1667(20)30251-3 |
| PMID | 33490980 |
| PMC | PMC7806515 |
| MeSH | Animals Hepatitis B / immunology Hepatitis B / therapy Hepatitis B Antigens / immunology* Hepatitis B virus / immunology* Humans Immunotherapy, Adoptive Induced Pluripotent Stem Cells / immunology* Mice T-Lymphocytes, Cytotoxic / immunology* |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | iPS-MEF-Ng-20D-17(APS0001) |