論文 - 詳細
| RRC ID | 64754 |
|---|---|
| 著者 | Hecker A, Anger P, Braaker PN, Schulze W, Schuster S. |
| タイトル | High-resolution mapping of injury-site dependent functional recovery in a single axon in zebrafish. |
| ジャーナル | Commun Biol |
| Abstract |
In non-mammalian vertebrates, some neurons can regenerate after spinal cord injury. One of these, the giant Mauthner (M-) neuron shows a uniquely direct link to a robust survival-critical escape behavior but appears to regenerate poorly. Here we use two-photon microscopy in parallel with behavioral assays in zebrafish to show that the M-axon can regenerate very rapidly and that the recovery of functionality lags by just days. However, we also find that the site of the injury is critical: While regeneration is poor both close and far from the soma, rapid regeneration and recovery of function occurs for injuries between 10% and 50% of total axon length. Our findings show that rapid regeneration and the recovery of function can be studied at remarkable temporal resolution after targeted injury of one single M-axon and that the decision between poor and rapid regeneration can be studied in this one axon. |
| 巻・号 | 3(1) |
| ページ | 307 |
| 公開日 | 2020-6-12 |
| DOI | 10.1038/s42003-020-1034-x |
| PII | 10.1038/s42003-020-1034-x |
| PMID | 32533058 |
| PMC | PMC7293241 |
| MeSH | Animals Animals, Genetically Modified Axons / physiology* Larva / physiology* Larva / radiation effects Lasers / adverse effects Microscopy, Fluorescence, Multiphoton / methods* Nerve Regeneration* Recovery of Function* Spinal Cord Injuries / physiopathology* Zebrafish |
| IF | 4.165 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 49 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | Tol-056 |