論文 - 詳細
| RRC ID | 64771 |
|---|---|
| 著者 | Wu Y, Dal Maschio M, Kubo F, Baier H. |
| タイトル | An Optical Illusion Pinpoints an Essential Circuit Node for Global Motion Processing. |
| ジャーナル | Neuron |
| Abstract |
Direction-selective (DS) neurons compute the direction of motion in a visual scene. Brain-wide imaging in larval zebrafish has revealed hundreds of DS neurons scattered throughout the brain. However, the exact population that causally drives motion-dependent behaviors-e.g., compensatory eye and body movements-remains largely unknown. To identify the behaviorally relevant population of DS neurons, here we employ the motion aftereffect (MAE), which causes the well-known "waterfall illusion." Together with region-specific optogenetic manipulations and cellular-resolution functional imaging, we found that MAE-responsive neurons represent merely a fraction of the entire population of DS cells in larval zebrafish. They are spatially clustered in a nucleus in the ventral lateral pretectal area and are necessary and sufficient to steer the entire cycle of optokinetic eye movements. Thus, our illusion-based behavioral paradigm, combined with optical imaging and optogenetics, identified key circuit elements of global motion processing in the vertebrate brain. |
| 巻・号 | 108(4) |
| ページ | 722-734.e5 |
| 公開日 | 2020-11-25 |
| DOI | 10.1016/j.neuron.2020.08.027 |
| PII | S0896-6273(20)30658-9 |
| PMID | 32966764 |
| MeSH | Afterimage / physiology* Animals Animals, Genetically Modified Eye Movements / physiology Motion Perception / physiology* Neuroimaging / methods Optical Illusions / physiology* Optogenetics Photic Stimulation Pretectal Region / physiology* Zebrafish |
| IF | 14.415 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 58 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | Tg(vglut2a:Gal4) SAGFF(LF)81C |