RRC ID 64771
Author Wu Y, Dal Maschio M, Kubo F, Baier H.
Title An Optical Illusion Pinpoints an Essential Circuit Node for Global Motion Processing.
Journal Neuron
Abstract Direction-selective (DS) neurons compute the direction of motion in a visual scene. Brain-wide imaging in larval zebrafish has revealed hundreds of DS neurons scattered throughout the brain. However, the exact population that causally drives motion-dependent behaviors-e.g., compensatory eye and body movements-remains largely unknown. To identify the behaviorally relevant population of DS neurons, here we employ the motion aftereffect (MAE), which causes the well-known "waterfall illusion." Together with region-specific optogenetic manipulations and cellular-resolution functional imaging, we found that MAE-responsive neurons represent merely a fraction of the entire population of DS cells in larval zebrafish. They are spatially clustered in a nucleus in the ventral lateral pretectal area and are necessary and sufficient to steer the entire cycle of optokinetic eye movements. Thus, our illusion-based behavioral paradigm, combined with optical imaging and optogenetics, identified key circuit elements of global motion processing in the vertebrate brain.
Volume 108(4)
Pages 722-734.e5
Published 2020-11-25
DOI 10.1016/j.neuron.2020.08.027
PII S0896-6273(20)30658-9
PMID 32966764
IF 14.415
Zebrafish Tg(vglut2a:Gal4)