| RRC ID |
64771
|
| 著者 |
Wu Y, Dal Maschio M, Kubo F, Baier H.
|
| タイトル |
An Optical Illusion Pinpoints an Essential Circuit Node for Global Motion Processing.
|
| ジャーナル |
Neuron
|
| Abstract |
Direction-selective (DS) neurons compute the direction of motion in a visual scene. Brain-wide imaging in larval zebrafish has revealed hundreds of DS neurons scattered throughout the brain. However, the exact population that causally drives motion-dependent behaviors-e.g., compensatory eye and body movements-remains largely unknown. To identify the behaviorally relevant population of DS neurons, here we employ the motion aftereffect (MAE), which causes the well-known "waterfall illusion." Together with region-specific optogenetic manipulations and cellular-resolution functional imaging, we found that MAE-responsive neurons represent merely a fraction of the entire population of DS cells in larval zebrafish. They are spatially clustered in a nucleus in the ventral lateral pretectal area and are necessary and sufficient to steer the entire cycle of optokinetic eye movements. Thus, our illusion-based behavioral paradigm, combined with optical imaging and optogenetics, identified key circuit elements of global motion processing in the vertebrate brain.
|
| 巻・号 |
108(4)
|
| ページ |
722-734.e5
|
| 公開日 |
2020-11-25
|
| DOI |
10.1016/j.neuron.2020.08.027
|
| PII |
S0896-6273(20)30658-9
|
| PMID |
32966764
|
| MeSH |
Afterimage / physiology*
Animals
Animals, Genetically Modified
Eye Movements / physiology
Motion Perception / physiology*
Neuroimaging / methods
Optical Illusions / physiology*
Optogenetics
Photic Stimulation
Pretectal Region / physiology*
Zebrafish
|
| IF |
14.415
|
| リソース情報 |
| ゼブラフィッシュ |
Tg(vglut2a:Gal4)
SAGFF(LF)81C |
