論文 - 詳細
| RRC ID | 64798 |
|---|---|
| 著者 | Zempo B, Yamamoto Y, Williams T, Ono F. |
| タイトル | Synaptic silencing of fast muscle is compensated by rewired innervation of slow muscle. |
| ジャーナル | Sci Adv |
| Abstract |
For decades, numerous studies have proposed that fast muscles contribute to quick movement, while slow muscles underlie locomotion requiring endurance. By generating mutant zebrafish whose fast muscles are synaptically silenced, we examined the contribution of fast muscles in both larval and adult zebrafish. In the larval stage, mutants lacked the characteristic startle response to tactile stimuli: bending of the trunk (C-bend) followed by robust forward propulsion. Unexpectedly, adult mutants with silenced fast muscles showed robust C-bends and forward propulsion upon stimulation. Retrograde labeling revealed that motor neurons genetically programmed to form synapses on fast muscles are instead rerouted and innervate slow muscles, which led to partial conversion of slow and intermediate muscles to fast muscles. Thus, extended silencing of fast muscle synapses changed motor neuron innervation and caused muscle cell type conversion, revealing an unexpected mechanism of locomotory adaptation. |
| 巻・号 | 6(15) |
| ページ | eaax8382 |
| 公開日 | 2020-4-1 |
| DOI | 10.1126/sciadv.aax8382 |
| PII | aax8382 |
| PMID | 32284992 |
| PMC | PMC7141830 |
| MeSH | Animals Animals, Genetically Modified Gene Knockdown Techniques Gene Targeting Genetic Loci Larva Locomotion Muscle Fibers, Fast-Twitch / physiology* Muscle Fibers, Slow-Twitch / physiology* Neuromuscular Junction / physiology* Receptors, Nicotinic / deficiency Synaptic Transmission Zebrafish |
| IF | 13.117 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | RIKEN WT |