Reference - Detail
| RRC ID | 64878 |
|---|---|
| Author | Wang Y, Toyoshima O, Kunimatsu J, Yamada H, Matsumoto M. |
| Title | Tonic firing mode of midbrain dopamine neurons continuously tracks reward values changing moment-by-moment. |
| Journal | Elife |
| Abstract |
Animal behavior is regulated based on the values of future rewards. The phasic activity of midbrain dopamine neurons signals these values. Because reward values often change over time, even on a subsecond-by-subsecond basis, appropriate behavioral regulation requires continuous value monitoring. However, the phasic dopamine activity, which is sporadic and has a short duration, likely fails continuous monitoring. Here, we demonstrate a tonic firing mode of dopamine neurons that effectively tracks changing reward values. We recorded dopamine neuron activity in monkeys during a Pavlovian procedure in which the value of a cued reward gradually increased or decreased. Dopamine neurons tonically increased and decreased their activity as the reward value changed. This tonic activity was evoked more strongly by non-burst spikes than burst spikes producing a conventional phasic activity. Our findings suggest that dopamine neurons change their firing mode to effectively signal reward values in a given situation. |
| Volume | 10 |
| Published | 2021-3-10 |
| DOI | 10.7554/eLife.63166 |
| PII | 63166 |
| PMID | 33689680 |
| PMC | PMC7946420 |
| MeSH | Animals Behavior, Animal Cues* Dopaminergic Neurons / physiology* Female Macaca fuscata / physiology* Male Mesencephalon / physiology* Reward* Time Factors |
| IF | 7.08 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 17 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Japanese macaques | |