論文 - 詳細
| RRC ID | 6498 |
|---|---|
| 著者 | Uraguchi M, Morikawa M, Shirakawa M, Sanada K, Imai K. |
| タイトル | Activation of WNT family expression and signaling in squamous cell carcinomas of the oral cavity. |
| ジャーナル | J Dent Res |
| Abstract |
The WNT family activates an oncogenic signaling mediated through beta-catenin and is up-regulated in a variety of malignant neoplasms. The signaling translocates beta-catenin into the nucleus and stimulates carcinoma cells in the epithelial-mesenchymal transition (EMT). However, WNT expression and signaling in oral carcinomas have not been examined. The present study focused on unveiling the involvement of WNTs in oral carcinomas, and showed that carcinoma cells express 11 of 19 WNT family members by reverse-transcription/PCR. WNT-expressing carcinoma cells exhibited increased beta-catenin levels in the cytoplasmic pool and translocation to the nucleus. The activation state of signaling correlated with the expression of membrane-type 1 matrix metalloproteinase, which degrades territorial matrices in carcinoma invasion. Immunohistochemistry disclosed that WNT3 expression and nuclear localization of beta-catenin were predominant in carcinoma cells at the invasive front. These results suggest that enhanced WNT expression and signaling accelerate the progression of carcinomas via activating EMTs and local invasiveness. |
| 巻・号 | 83(4) |
| ページ | 327-32 |
| 公開日 | 2004-4-1 |
| DOI | 10.1177/154405910408300411 |
| PMID | 15044508 |
| MeSH | Carcinoma, Squamous Cell / genetics* Carcinoma, Squamous Cell / metabolism Cytoskeletal Proteins / metabolism Gene Expression Profiling* Gene Expression Regulation, Neoplastic* Humans Mouth Neoplasms / genetics* Mouth Neoplasms / metabolism Multigene Family Proto-Oncogene Proteins / genetics* Proto-Oncogene Proteins / metabolism Signal Transduction Trans-Activators / metabolism Tumor Cells, Cultured Wnt Proteins Zebrafish Proteins* beta Catenin |
| IF | 4.914 |
| 引用数 | 64 |
| WOS 分野 | DENTISTRY, ORAL SURGERY & MEDICINE |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | SCCKN(RCB0441) |