| RRC ID |
6503
|
| 著者 |
Miyata S, Uchinokura S, Fukushima T, Hamasuna R, Itoh H, Akiyama Y, Nakano S, Wakisaka S, Kataoka H.
|
| タイトル |
Diverse roles of hepatocyte growth factor activator inhibitor type 1 (HAI-1) in the growth of glioblastoma cells in vivo.
|
| ジャーナル |
Cancer Lett
|
| Abstract |
Hepatocyte growth factor activator inhibitor type-1 (HAI-1) is an integral-membrane proteinase inhibitor. In this study, we examined the effects of HAI-1 on human glioblastoma cells. Two glioblastoma cell lines (YKG-1, U251) were stably transfected with expression plasmid harboring mature membrane-form or truncated secreted-form HAI-1. Culture characteristics were not altered by the expression of HAI-1, whereas in vitro invasiveness of U251 was suppressed. On the other hand, the expression of membrane-form HAI-1 resulted in significantly enhanced tumorigenicity of both cell lines in vivo. In contrast, secreted-form HAI-1 did not promote the tumorigenicity. These results suggest that HAI-1 may play complex roles in progression of glioblastoma cells, and membrane-form HAI-1 may mediate an undefined important signaling in the cells.
|
| 巻・号 |
227(1)
|
| ページ |
83-93
|
| 公開日 |
2005-9-8
|
| DOI |
10.1016/j.canlet.2005.01.010
|
| PII |
S0304-3835(05)00041-8
|
| PMID |
16051034
|
| MeSH |
Animals
Cell Line, Tumor
Glioblastoma / pathology*
Humans
Male
Membrane Glycoproteins / genetics
Membrane Glycoproteins / physiology*
Mice
Mice, Inbred BALB C
Proteinase Inhibitory Proteins, Secretory
|
| IF |
7.36
|
| 引用数 |
9
|
|
WOS 分野
|
ONCOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
KG-1-C(RCB0270) |
