論文 - 詳細
| RRC ID | 6503 |
|---|---|
| 著者 | Miyata S, Uchinokura S, Fukushima T, Hamasuna R, Itoh H, Akiyama Y, Nakano S, Wakisaka S, Kataoka H. |
| タイトル | Diverse roles of hepatocyte growth factor activator inhibitor type 1 (HAI-1) in the growth of glioblastoma cells in vivo. |
| ジャーナル | Cancer Lett |
| Abstract |
Hepatocyte growth factor activator inhibitor type-1 (HAI-1) is an integral-membrane proteinase inhibitor. In this study, we examined the effects of HAI-1 on human glioblastoma cells. Two glioblastoma cell lines (YKG-1, U251) were stably transfected with expression plasmid harboring mature membrane-form or truncated secreted-form HAI-1. Culture characteristics were not altered by the expression of HAI-1, whereas in vitro invasiveness of U251 was suppressed. On the other hand, the expression of membrane-form HAI-1 resulted in significantly enhanced tumorigenicity of both cell lines in vivo. In contrast, secreted-form HAI-1 did not promote the tumorigenicity. These results suggest that HAI-1 may play complex roles in progression of glioblastoma cells, and membrane-form HAI-1 may mediate an undefined important signaling in the cells. |
| 巻・号 | 227(1) |
| ページ | 83-93 |
| 公開日 | 2005-9-8 |
| DOI | 10.1016/j.canlet.2005.01.010 |
| PII | S0304-3835(05)00041-8 |
| PMID | 16051034 |
| MeSH | Animals Cell Line, Tumor Glioblastoma / pathology* Humans Male Membrane Glycoproteins / genetics Membrane Glycoproteins / physiology* Mice Mice, Inbred BALB C Proteinase Inhibitory Proteins, Secretory |
| IF | 7.36 |
| 引用数 | 9 |
| WOS 分野 | ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | KG-1-C(RCB0270) |