論文 - 詳細
| RRC ID | 65047 |
|---|---|
| 著者 | Nguyen HX, Nguyen MTT, Nguyen NT, Awale S. |
| タイトル | Chemical Constituents of Propolis from Vietnamese Trigona minor and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line. |
| ジャーナル | J Nat Prod |
| Abstract |
The ethanol extract of propolis from the Vietnamese stingless bee Trigona minor possessed potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells in nutrient-deprived medium, with a PC50 value of 14.0 μg/mL. Chemical investigation of this extract led to the isolation of 15 cycloartane-type triterpenoids, including five new compounds (1-5), and a lanostane-type triterpenoid. The structures of the new compounds were elucidated on the basis of NMR spectroscopic analysis. Among the isolated compounds, 23-hydroxyisomangiferolic acid B (5) and 27-hydroxyisomangiferolic acid (13) exhibited the most potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrition-deprived conditions, with PC50 values of 4.3 and 3.7 μM, respectively. |
| 巻・号 | 80(8) |
| ページ | 2345-2352 |
| 公開日 | 2017-8-25 |
| DOI | 10.1021/acs.jnatprod.7b00375 |
| PMID | 28783356 |
| MeSH | Animals Antineoplastic Agents, Phytogenic / chemistry Cell Line, Tumor Drug Screening Assays, Antitumor Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pancreatic Neoplasms / drug therapy* Propolis / chemistry* Triterpenes / chemistry Triterpenes / isolation & purification* Triterpenes / pharmacology* Vietnam |
| IF | 3.782 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | PANC-1(RCB2095) |