RRC ID 65086
著者 Jeong SY, Son HJ.
タイトル Effects of mycosubtilin homolog algicides from a marine bacterium, Bacillus sp. SY-1, against the harmful algal bloom species Cochlodinium polykrikoides.
ジャーナル J Microbiol
Abstract The marine bacterium, Bacillus sp. SY-1, produced algicidal compounds that are notably active against the bloom-forming alga Cochlodinium polykrikoides. We isolated three algicidal compounds and identified these as mycosubtilins with molecular weights of 1056, 1070, and 1084 (designated MS 1056, 1070, and 1084, respectively), based on amino acid analyses and 1H, 13C, and two-dimensional nuclear magnetic resonance spectroscopy, including 1H-15N heteronuclear multiple bond correlation analysis. MS 1056 contains a β-amino acid residue with an alkyl side chain of C15, which has not previously been seen in known mycosubtilin families. MS 1056, 1070, and 1084 showed algicidal activities against C. polykrikoides with 6-h LC50 values of 2.3 ± 0.4, 0.8 ± 0.2, and 0.6 ± 0.1 μg/ml, respectively. These compounds also showed significant algicidal activities against other harmful algal bloom species. In contrast, MS 1084 showed no significant growth inhibitory effects against other organisms, including bacteria and microalgae, although does inhibit the growth of some fungi and yeasts. These observations imply that the algicidal bacterium Bacillus sp. SY-1 and its algicidal compounds could play an important role in regulating the onset and development of harmful algal blooms in natural environments.
巻・号 59(4)
ページ 389-400
公開日 2021-4-1
DOI 10.1007/s12275-021-1086-8
PII 10.1007/s12275-021-1086-8
PMID 33779952
MeSH Aquatic Organisms Bacillus / chemistry* Bacillus / isolation & purification Bacterial Proteins / chemistry Bacterial Proteins / pharmacology DNA, Bacterial Dinoflagellida / drug effects* Harmful Algal Bloom / drug effects* Herbicides / chemistry Herbicides / pharmacology* Lipoproteins / chemistry Lipoproteins / pharmacology Phylogeny RNA, Ribosomal, 16S
IF 2.845
リソース情報
藻類 NIES-23 NIES-227 NIES-238 NIES-298 NIES-316 NIES-446 NIES-682