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RRC ID 65236
Author Shin MG, Lee JW, Han JS, Lee B, Jeong JH, Park SH, Kim JH, Jang S, Park M, Kim SY, Kim S, Yang YR, Kim JY, Hoe KL, Park C, Lee KP, Kwon KS, Kwon ES.
Title Bacteria-derived metabolite, methylglyoxal, modulates the longevity of C. elegans through TORC2/SGK-1/DAF-16 signaling.
Journal Proc Natl Acad Sci U S A
Volume 117(29)
Pages 17142-17150
Published 2020-7-21
DOI 10.1073/pnas.1915719117
PII 1915719117
PMID 32636256
PMC PMC7382248
MeSH Animals Caenorhabditis elegans* / drug effects Caenorhabditis elegans* / metabolism Caenorhabditis elegans* / microbiology Caenorhabditis elegans Proteins / metabolism* Escherichia coli / metabolism Forkhead Transcription Factors / metabolism* Gastrointestinal Microbiome / physiology Longevity / drug effects* Mechanistic Target of Rapamycin Complex 2 / metabolism Models, Biological Protein Serine-Threonine Kinases / metabolism* Pyruvaldehyde* / metabolism Pyruvaldehyde* / pharmacology Signal Transduction / drug effects Transcriptome / genetics
Resource
C.elegans tm1108