論文 - 詳細
| RRC ID | 65241 |
|---|---|
| 著者 | Starich TA, Bai X, Greenstein D. |
| タイトル | Gap junctions deliver malonyl-CoA from soma to germline to support embryogenesis in Caenorhabditis elegans. |
| ジャーナル | Elife |
| Abstract |
Gap junctions are ubiquitous in metazoans and play critical roles in important biological processes, including electrical conduction and development. Yet, only a few defined molecules passing through gap junction channels have been linked to specific functions. We isolated gap junction channel mutants that reduce coupling between the soma and germ cells in the Caenorhabditis elegans gonad. We provide evidence that malonyl-CoA, the rate-limiting substrate for fatty acid synthesis (FAS), is produced in the soma and delivered through gap junctions to the germline; there it is used in fatty acid synthesis to critically support embryonic development. Separation of malonyl-CoA production from its site of utilization facilitates somatic control of germline development. Additionally, we demonstrate that loss of malonyl-CoA production in the intestine negatively impacts germline development independently of FAS. Our results suggest that metabolic outsourcing of malonyl-CoA may be a strategy by which the soma communicates nutritional status to the germline. |
| 巻・号 | 9 |
| 公開日 | 2020-7-31 |
| DOI | 10.7554/eLife.58619 |
| PII | 58619 |
| PMID | 32735213 |
| PMC | PMC7445009 |
| MeSH | Animals Caenorhabditis elegans / embryology* Caenorhabditis elegans / enzymology Caenorhabditis elegans / genetics Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism Embryo, Nonmammalian / embryology Embryo, Nonmammalian / metabolism Embryonic Development / genetics* Gap Junctions / physiology Germ Cells / growth & development* Gonads / growth & development Malonyl Coenzyme A / genetics* Malonyl Coenzyme A / metabolism |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 8 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tmIs1236 |