Reference - Detail
| RRC ID | 65252 |
|---|---|
| Author | Kew C, Huang W, Fischer J, Ganesan R, Robinson N, Antebi A. |
| Title | Evolutionarily conserved regulation of immunity by the splicing factor RNP-6/PUF60. |
| Journal | Elife |
| Abstract |
Splicing is a vital cellular process that modulates important aspects of animal physiology, yet roles in regulating innate immunity are relatively unexplored. From genetic screens in C. elegans, we identified splicing factor RNP-6/PUF60 whose activity suppresses immunity, but promotes longevity, suggesting a tradeoff between these processes. Bacterial pathogen exposure affects gene expression and splicing in a rnp-6 dependent manner, and rnp-6 gain and loss-of-function activities reveal an active role in immune regulation. Another longevity promoting splicing factor, SFA-1, similarly exerts an immuno-suppressive effect, working downstream or parallel to RNP-6. RNP-6 acts through TIR-1/PMK-1/MAPK signaling to modulate immunity. The mammalian homolog, PUF60, also displays anti-inflammatory properties, and its levels swiftly decrease after bacterial infection in mammalian cells, implying a role in the host response. Altogether our findings demonstrate an evolutionarily conserved modulation of immunity by specific components of the splicing machinery. |
| Volume | 9 |
| Published | 2020-6-15 |
| DOI | 10.7554/eLife.57591 |
| PII | 57591 |
| PMID | 32538777 |
| PMC | PMC7332298 |
| MeSH | Alternative Splicing Animals Anti-Inflammatory Agents Bacterial Infections / metabolism Caenorhabditis elegans / metabolism* Caenorhabditis elegans / microbiology Caenorhabditis elegans Proteins / metabolism DNA-Binding Proteins / metabolism Escherichia coli Gene Expression HeLa Cells Humans Immunity, Innate* Longevity / genetics Male Mice Mitogen-Activated Protein Kinases / metabolism RAW 264.7 Cells RNA Splicing Factors / metabolism* RNA, Messenger / metabolism Repressor Proteins / metabolism* Signal Transduction Staphylococcus aureus |
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 39 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm3036 tm1978 |