論文 - 詳細
| RRC ID | 65269 |
|---|---|
| 著者 | Borbolis F, Rallis J, Kanatouris G, Kokla N, Karamalegkos A, Vasileiou C, Vakaloglou KM, Diallinas G, Stravopodis DJ, Zervas CG, Syntichaki P. |
| タイトル | mRNA decapping is an evolutionarily conserved modulator of neuroendocrine signaling that controls development and ageing. |
| ジャーナル | Elife |
| Abstract |
Eukaryotic 5'-3' mRNA decay plays important roles during development and in response to stress, regulating gene expression post-transcriptionally. In Caenorhabditis elegans, deficiency of DCAP-1/DCP1, the essential co-factor of the major cytoplasmic mRNA decapping enzyme, impacts normal development, stress survival and ageing. Here, we show that overexpression of dcap-1 in neurons of worms is sufficient to increase lifespan through the function of the insulin/IGF-like signaling and its effector DAF-16/FOXO transcription factor. Neuronal DCAP-1 affects basal levels of INS-7, an ageing-related insulin-like peptide, which acts in the intestine to determine lifespan. Short-lived dcap-1 mutants exhibit a neurosecretion-dependent upregulation of intestinal ins-7 transcription, and diminished nuclear localization of DAF-16/FOXO. Moreover, neuronal overexpression of DCP1 in Drosophila melanogaster confers longevity in adults, while neuronal DCP1 deficiency shortens lifespan and affects wing morphogenesis, cell non-autonomously. Our genetic analysis in two model-organisms suggests a critical and conserved function of DCAP-1/DCP1 in developmental events and lifespan modulation. |
| 巻・号 | 9 |
| 公開日 | 2020-5-5 |
| DOI | 10.7554/eLife.53757 |
| PII | 53757 |
| PMID | 32366357 |
| PMC | PMC7200159 |
| MeSH | Aging / genetics* Aging / physiology Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / growth & development Caenorhabditis elegans / physiology Caenorhabditis elegans Proteins / physiology Drosophila Proteins / physiology Drosophila melanogaster / genetics Drosophila melanogaster / growth & development Drosophila melanogaster / physiology Endoribonucleases / physiology Forkhead Transcription Factors / physiology Gene Expression Regulation, Developmental / genetics Neurons / physiology Neurosecretory Systems / growth & development Neurosecretory Systems / physiology* RNA Stability / genetics* RNA Stability / physiology RNA, Messenger / genetics* RNA, Messenger / physiology |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 14 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm3163 |