Reference - Detail
| RRC ID | 65272 |
|---|---|
| Author | Madhu B, Lakdawala MF, Issac NG, Gumienny TL. |
| Title | Caenorhabditis elegans saposin-like spp-9 is involved in specific innate immune responses. |
| Journal | Genes Immun |
| Abstract |
Animals counter specific environmental challenges with a combination of broad and tailored host responses. One protein family enlisted in the innate immune response includes the saposin-like antimicrobial proteins. We investigated the expression of a Caenorhabditis elegans saposin-like gene, spp-9, in response to different stresses. spp-9 expression was detected in the intestine and six amphid neurons, including AWB and AWC. spp-9 expression is increased in response to starvation stress. In addition, we discovered pathogen-specific regulation of spp-9 that was not clearly demarcated by Gram nature of the bacterial challenge. Multiple molecular innate immune response pathways, including DBL-1/TGF-β-like, insulin-like, and p38/MAPK, regulate expression of spp-9. Our results suggest spp-9 is involved in targeted responses to a variety of abiotic and bacterial challenges that are coordinated by multiple signaling pathways. |
| Volume | 21(5) |
| Pages | 301-310 |
| Published | 2020-11-1 |
| DOI | 10.1038/s41435-020-0108-6 |
| PII | 10.1038/s41435-020-0108-6 |
| PMID | 32770079 |
| PMC | PMC7652716 |
| MeSH | Animals Caenorhabditis elegans Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Immunity, Innate* MAP Kinase Signaling System Neuropeptides / metabolism Saposins / genetics Saposins / metabolism* Stress, Physiological Transforming Growth Factor beta / metabolism p38 Mitogen-Activated Protein Kinases / metabolism |
| Altmetric score |
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 14 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm3036 |