論文 - 詳細
| RRC ID | 65280 |
|---|---|
| 著者 | Li Y, Ding W, Li CY, Liu Y. |
| タイトル | HLH-11 modulates lipid metabolism in response to nutrient availability. |
| ジャーナル | Nat Commun |
| Abstract |
The ability of organisms to sense nutrient availability and tailor their metabolic states to withstand nutrient deficiency is critical for survival. To identify previously unknown regulators that couple nutrient deficiency to body fat utilization, we performed a cherry-picked RNAi screen in C. elegans and found that the transcription factor HLH-11 regulates lipid metabolism in response to food availability. In well-fed worms, HLH-11 suppresses transcription of lipid catabolism genes. Upon fasting, the HLH-11 protein level is reduced through lysosome- and proteasome-mediated degradation, thus alleviating the inhibitory effect of HLH-11, activating the transcription of lipid catabolism genes, and utilizing fat. Additionally, lipid profiling revealed that reduction in the HLH-11 protein level remodels the lipid landscape in C. elegans. Moreover, TFAP4, the mammalian homolog of HLH-11, plays an evolutionarily conserved role in regulating lipid metabolism in response to starvation. Thus, TFAP4 may represent a potential therapeutic target for lipid storage disorders. |
| 巻・号 | 11(1) |
| ページ | 5959 |
| 公開日 | 2020-11-24 |
| DOI | 10.1038/s41467-020-19754-1 |
| PII | 10.1038/s41467-020-19754-1 |
| PMID | 33235199 |
| PMC | PMC7686365 |
| MeSH | Animals Basic Helix-Loop-Helix Transcription Factors* / genetics Basic Helix-Loop-Helix Transcription Factors* / metabolism Caenorhabditis elegans* / genetics Caenorhabditis elegans* / metabolism Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Gene Expression Regulation Lipid Metabolism / genetics* RNA Interference Starvation / metabolism |
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オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm4063 |