論文 - 詳細
| RRC ID | 65310 |
|---|---|
| 著者 | Liu P, Chen B, Wang ZW. |
| タイトル | GABAergic motor neurons bias locomotor decision-making in C. elegans. |
| ジャーナル | Nat Commun |
| Abstract |
Proper threat-reward decision-making is critical to animal survival. Emerging evidence indicates that the motor system may participate in decision-making but the neural circuit and molecular bases for these functions are little known. We found in C. elegans that GABAergic motor neurons (D-MNs) bias toward the reward behavior in threat-reward decision-making by retrogradely inhibiting a pair of premotor command interneurons, AVA, that control cholinergic motor neurons in the avoidance neural circuit. This function of D-MNs is mediated by a specific ionotropic GABA receptor (UNC-49) in AVA, and depends on electrical coupling between the two AVA interneurons. Our results suggest that AVA are hub neurons where sensory inputs from threat and reward sensory modalities and motor information from D-MNs are integrated. This study demonstrates at single-neuron resolution how motor neurons may help shape threat-reward choice behaviors through interacting with other neurons. |
| 巻・号 | 11(1) |
| ページ | 5076 |
| 公開日 | 2020-10-8 |
| DOI | 10.1038/s41467-020-18893-9 |
| PII | 10.1038/s41467-020-18893-9 |
| PMID | 33033264 |
| PMC | PMC7544903 |
| MeSH | Animals Avoidance Learning Bias Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / metabolism Chemotaxis Electrophysiological Phenomena GABAergic Neurons / metabolism* Gap Junctions / metabolism Glycerol / pharmacology Interneurons / metabolism Locomotion / physiology* Motor Neurons / metabolism* Optogenetics Osmolar Concentration Receptors, Cholinergic / metabolism Synapses / metabolism |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2738 tm2071 |