論文 - 詳細
| RRC ID | 65324 |
|---|---|
| 著者 | Saitoh Y, Katane M, Miyamoto T, Sekine M, Sakai-Kato K, Homma H. |
| タイトル | d-Serine and d-Alanine Regulate Adaptive Foraging Behavior in Caenorhabditis elegans via the NMDA Receptor. |
| ジャーナル | J Neurosci |
| Abstract |
d-Serine (d-Ser) is a coagonist for NMDA-type glutamate receptors and is thus important for higher brain function. d-Ser is synthesized by serine racemase and degraded by d-amino acid oxidase. However, the significance of these enzymes and the relevant functions of d-amino acids remain unclear. Here, we show that in the nematode Caenorhabditis elegans, the serine racemase homolog SERR-1 and d-amino acid oxidase DAAO-1 control an adaptive foraging behavior. Similar to many organisms, C. elegans immediately initiates local search for food when transferred to a new environment. With prolonged food deprivation, the worms exhibit a long-range dispersal behavior as the adaptive foraging strategy. We found that serr-1 deletion mutants did not display this behavior, whereas daao-1 deletion mutants immediately engaged in long-range dispersal after food removal. A quantitative analysis of d-amino acids indicated that d-Ser and d-alanine (d-Ala) are both synthesized and suppressed during food deprivation. A behavioral pharmacological analysis showed that the long-range dispersal behavior requires NMDA receptor desensitization. Long-term pretreatment with d-Ala, as well as with an NMDA receptor agonist, expanded the area searched by wild-type worms immediately after food removal, whereas pretreatment with d-Ser did not. We propose that d-Ser and d-Ala are endogenous regulators that cooperatively induce the long-range dispersal behavior in C. elegans through actions on the NMDA receptor.SIGNIFICANCE STATEMENT In mammals, d-serine (d-Ser) functions as an important neuromodulator of the NMDA-type glutamate receptor, which regulates higher brain functions. In Caenorhabditis elegans, previous studies failed to clearly define the physiological significance of d-Ser, d-alanine (d-Ala), and their metabolic enzymes. In this study, we found that these d-amino acids and their associated enzymes are active during food deprivation, leading to an adaptive foraging behavior. We also found that this behavior involved NMDA receptor desensitization. |
| 巻・号 | 40(39) |
| ページ | 7531-7544 |
| 公開日 | 2020-9-23 |
| DOI | 10.1523/JNEUROSCI.2358-19.2020 |
| PII | JNEUROSCI.2358-19.2020 |
| PMID | 32855271 |
| PMC | PMC7511192 |
| MeSH | Alanine / metabolism Alanine / pharmacology* Animals Brain / drug effects Brain / metabolism Brain / physiology Caenorhabditis elegans Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* D-Amino-Acid Oxidase / genetics D-Amino-Acid Oxidase / metabolism Feeding Behavior* Movement Racemases and Epimerases / genetics Racemases and Epimerases / metabolism Receptors, N-Methyl-D-Aspartate / metabolism* Serine / metabolism Serine / pharmacology* |
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オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm3673 tm1988 tm3785 |