Reference - Detail
| RRC ID | 65353 |
|---|---|
| Author | Bhoi A, Palladino F, Fabrizio P. |
| Title | Auxin confers protection against ER stress in Caenorhabditis elegans. |
| Journal | Biol Open |
| Abstract |
Auxins are plant growth regulators that influence most aspects of plant development through complex mechanisms. The development of an auxin-inducible degradation (AID) system has enabled rapid, conditional protein depletion in yeast and cultured cells. More recently, the system was successfully adapted to Caenorhabditiselegans to achieve auxin-dependent degradation of targets in all tissues and developmental stages. Whether auxin treatment alone has an impact on nematode physiology is an open question. Here we show that indole-3-acetic acid (IAA), the auxin most commonly used to trigger AID in worms, functions through the conserved IRE-1/XBP-1 branch of the Unfolded Protein Response (UPR) to promote resistance to endoplasmic reticulum (ER) stress. Because the UPR not only plays a central role in restoring ER homeostasis, but also promotes lipid biosynthesis and regulates lifespan, we suggest that extreme caution should be exercised when using the AID system to study these and related processes. |
| Volume | 10(2) |
| Published | 2021-2-3 |
| DOI | 10.1242/bio.057992 |
| PII | bio.057992 |
| PMID | 33495210 |
| PMC | PMC7875485 |
| MeSH | Animals Caenorhabditis elegans Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Embryonic Development / drug effects Endoplasmic Reticulum / metabolism Endoplasmic Reticulum Stress / drug effects* Indoleacetic Acids / pharmacology* Protective Agents / pharmacology* Unfolded Protein Response / drug effects |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | X(Twitter) |
| Total number of mentions | 7 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm2457 |