論文 - 詳細
| RRC ID | 65374 |
|---|---|
| 著者 | Meyer DH, Schumacher B. |
| タイトル | BiT age: A transcriptome-based aging clock near the theoretical limit of accuracy. |
| ジャーナル | Aging Cell |
| Abstract |
Aging clocks dissociate biological from chronological age. The estimation of biological age is important for identifying gerontogenes and assessing environmental, nutritional, or therapeutic impacts on the aging process. Recently, methylation markers were shown to allow estimation of biological age based on age-dependent somatic epigenetic alterations. However, DNA methylation is absent in some species such as Caenorhabditis elegans and it remains unclear whether and how the epigenetic clocks affect gene expression. Aging clocks based on transcriptomes have suffered from considerable variation in the data and relatively low accuracy. Here, we devised an approach that uses temporal scaling and binarization of C. elegans transcriptomes to define a gene set that predicts biological age with an accuracy that is close to the theoretical limit. Our model accurately predicts the longevity effects of diverse strains, treatments, and conditions. The involved genes support a role of specific transcription factors as well as innate immunity and neuronal signaling in the regulation of the aging process. We show that this binarized transcriptomic aging (BiT age) clock can also be applied to human age prediction with high accuracy. The BiT age clock could therefore find wide application in genetic, nutritional, environmental, and therapeutic interventions in the aging process. |
| 巻・号 | 20(3) |
| ページ | e13320 |
| 公開日 | 2021-3-1 |
| DOI | 10.1111/acel.13320 |
| PMID | 33656257 |
| PMC | PMC7963339 |
| MeSH | Aging / genetics* Biological Clocks / genetics* Fibroblasts / metabolism Humans Immunity, Innate / genetics Mutation / genetics Neurons / metabolism Signal Transduction Stress, Physiological / genetics Time Factors Transcriptome / genetics* |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 440 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 11.5 |
| リソース情報 | |
| 線虫 | tm1297 tm2149 |