| RRC ID |
65376
|
| Author |
Tataridas-Pallas N, Thompson MA, Howard A, Brown I, Ezcurra M, Wu Z, Silva IG, Saunter CD, Kuerten T, Weinkove D, Blackwell TK, Tullet JMA.
|
| Title |
Neuronal SKN-1B modulates nutritional signalling pathways and mitochondrial networks to control satiety.
|
| Journal |
PLoS Genet
|
| Abstract |
The feeling of hunger or satiety results from integration of the sensory nervous system with other physiological and metabolic cues. This regulates food intake, maintains homeostasis and prevents disease. In C. elegans, chemosensory neurons sense food and relay information to the rest of the animal via hormones to control food-related behaviour and physiology. Here we identify a new component of this system, SKN-1B which acts as a central food-responsive node, ultimately controlling satiety and metabolic homeostasis. SKN-1B, an ortholog of mammalian NF-E2 related transcription factors (Nrfs), has previously been implicated with metabolism, respiration and the increased lifespan incurred by dietary restriction. Here we show that SKN-1B acts in two hypothalamus-like ASI neurons to sense food, communicate nutritional status to the organism, and control satiety and exploratory behaviours. This is achieved by SKN-1B modulating endocrine signalling pathways (IIS and TGF-β), and by promoting a robust mitochondrial network. Our data suggest a food-sensing and satiety role for mammalian Nrf proteins.
|
| Volume |
17(3)
|
| Pages |
e1009358
|
| Published |
2021-3-1
|
| DOI |
10.1371/journal.pgen.1009358
|
| PII |
PGENETICS-D-20-01691
|
| PMID |
33661901
|
| PMC |
PMC7932105
|
| MeSH |
Animal Nutritional Physiological Phenomena*
Animals
Behavior, Animal
Caenorhabditis elegans / genetics
Caenorhabditis elegans / metabolism*
Caenorhabditis elegans Proteins / metabolism*
DNA-Binding Proteins / metabolism*
Mitochondria / metabolism*
Models, Biological
Muscles / metabolism
Neurons / metabolism*
Signal Transduction*
Transcription Factors / metabolism*
Transforming Growth Factor beta / metabolism
|
| Resource |
| C.elegans |
tm4241 |
